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Postdoc Research Fellow, Evolution of Host-Pathogen Interactions
The Reinke lab in the department of molecular genetics at the University of Toronto has an opening for a postdoctoral fellow. Our lab is interested in the evolution of parasites and immunity. We use C. elegans and related nematodes as model hosts to investigate infections by natural pathogens including microsporidia, bacteria, and fungi. Microsporidia are prevalent intracellular eukaryotic parasites that have the smallest eukaryotic genomes (some with only ~2000 proteins!) and are a fascinating system for exploring pathogen evolution. Recent work from the lab has been on identifying genetic variants that cause resistance or sensitivity to microsporidia infection, an immune response against microsporidia that is transferred between generations, a host factor that facilitates microsporidia cell invasion, inhibitors of microsporidia proliferation and invasion, and how bacteria influence microsporidia infection. We use a variety of experimental and computational research methods including genetics, genomics, bioinformatics, cell biology, and biochemistry. Potential projects include high-throughput approaches for identifying genetic variants that influence disease susceptibility to various pathogens, genomic approaches to study microsporidia evolution/diversity, and determining the mechanisms of intergenerational immunity. We are open to candidates bringing new ideas and techniques to the lab. My lab aims to provide a supportive and nurturing environment to allow lab members to achieve their scientific and career goals. We are part of a dynamic department of over 100 research groups working in a variety of diverse areas with many opportunities for collaborations.
We encourage candidates with a Ph.D. (or soon to obtain a Ph.D.) to apply by sending their CV, including contact information of 2-3 references, and a brief cover letter explaining previous research, current interests, and career goals. We encourage applications from diverse backgrounds to apply. Start date is flexible. The position is for 2-3 years with the possibility for renewal. Please see our website for more information on our group and the research that we do: https://www.reinkelab.org/
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