肱骨内生软骨瘤

教育   2024-11-21 18:05   江苏  

来源:熊猫放射


病史

43岁女性,肱骨无症状病变。(A 43-year-old woman with asymptomatic lesion seen in humerus.)

影像学表现

X线片(a)及其放大后的影像(b)显示肱骨近段骨干病变(a lesion in the proximal humeral diaphysis),内见斑点状中心性钙化(containing punctuate central calcifications),内侧皮质轻度骨膜扇贝样改变,累及范围小于骨皮质厚度的2/3(mild endosteal scalloping of the medial cortex involving <2/3 of the thickness)。未见相关的骨膜反应或骨皮质穿透(no associated periostitis or cortical breakthrough)。

CT图像(c和d)证实其为软骨性病变,内见钙化,肱骨内侧皮质轻度骨内膜扇贝样改变confirms the presence of a chondroid lesion with punctuate calcifications and mild endosteal scalloping of the medial humeral cortex)。

鉴别诊断(前3位)

  • 内生软骨瘤 Enchondroma

  • 骨梗死 Bone infarct

  • 软骨肉瘤 Chondrosarcoma


讨论
本例诊断的第一步是确定是否有软骨样基质的存在(determining whether chondroid matrix is present)。尽管该病变的钙化比典型内生软骨瘤少(has fewer calcifications than the typical enchondroma),但其斑点样表现和中心性钙化提示为软骨性病变(the punctate morphology and central location of the calcifications suggests a chondroid lesion)。骨梗死则常见边界清楚的硬化缘(Bone infarcts tend to have well-demarcated sclerotic borders. )。
肱骨内侧皮质的骨膜贝壳样改变应考虑高级别软骨性病变的可能(the scalloping of the medial humeral cortex should raise some concern for a higher grade chondroid lesion)。骨内膜受累大于骨皮质厚度的2/3是鉴别内生软骨瘤和低度恶性软骨肉瘤的最佳特征(Endosteal scalloping of >2/3 of the cortical thickness is the best distinguishing feature between an enchondroma and a low grade chondrosarcoma.)。该病变可见约25%的骨皮质受累,因此仍在内生软骨瘤的正常范围。(This lesion has roughly 25% cortical scalloping, thus is still within normal limits for an enchondroma.

诊断
  • 内生软骨瘤 
    Enchondroma

要点
  • 内生软骨瘤非常常见。Enchondromas are very common.

  • 病变典型呈现分叶状,由于透明软骨的分叶状生长所致(表面积的增大可更好地利用邻近的营养物质)。Lesions typically have a lobulated appearance due to lobulated growth of hyaline cartilage (increased surface area allows better use of adjacent nutrients).

  • 骨皮质的骨膜贝壳样改变(在其他因素中)有助于区分内生软骨瘤和软骨肉瘤。Endosteal scalloping of the cortex (amongst other factors) can help distinguish an enchondroma from chondrosarcoma.

  • CT对于描述骨膜贝壳样改变的程度非常有价值。CT is very useful in depicting the degree of endosteal scalloping.

  • 出现其他特征,如骨膜反应、骨皮质穿透、软组织肿块、病变较大(>5cm),应该考虑低度恶性软骨肉瘤或去分化成更高级别软骨肉瘤的可能。Other features, such as periosteal reaction, cortical breakthrough, soft tissue extension, and large lesion size (>5 cm), would raise concern for either a low grade chondrosarcoma or dedifferentiation into a higher grade chondrosarcoma.


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