报告人
Hiroaki Wake, MD, PhD
Professor,
Nagoya University Graduate School of Medicine
Multi-cellular dynamics
and their manipulation
主持人：
Akihiro Yamanaka博士
报告时间：
2024年8月29日
10:00-11:00
报告地点：
北京脑科学与类脑研究所
二期X102报告厅
报告摘要
Multi-cellular dynamics and their manipulation
The interaction of neuron and glia is essential for functional neuronal circuits. We have been especially focused on microglia, a sole immune cell in CNS. In addition to the pathological function of microglia, recent developments in molecular probes and optical imaging in vivo have revealed that microglia are highly motile cell in the healthy brain, extending and retracting their process that extend from a largely stationary cell soma. We reveal their physiological and pathological function on synapse and vessels. In this session, we will show microglial role for cross modal plasticity and show how they can contribute on sensory discrimination by their effect on neural circuit function. In addition, we will introduce our recent developed holographic microscope that can precisely measure and manipulate neuron and glial cell activities in a spatiotemporal manner in living mice to ultimately affect on behavior output. Furthermore, we will show our successful evaluation method to analyze the functional neuronal connectivity to integrate the transcriptome information.
Dr. Hiroaki Wake holds an M.D. from Nagoya City University School of Medicine, which he earned in 2001, followed by a Ph.D. in 2007 under the mentorship of Prof. Junichi Nabekura. Dr. Wake serves in various esteemed positions, including as a Research Fellow at the National Institute for Physiological Sciences and a Visiting Fellow at the National Institute of Health. His expertise in neurology and neuroscience has been recognized with awards such as The Young Scientists’ Prize and the NIH Fellows Award for Research Excellence.
Currently, Dr. Wake is a Professor at the Department of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of Medicine, and also holds a cross-appointment as a Professor at the Division of Multicellular Circuit Dynamics, National Institute for Physiological Sciences. His ground-breaking research spans a wide array of topics, from the role of astrocytes in epilepsy to the impact of myelin plasticity on learning and behaviour. Dr. Wake's contributions to the field have been significant, with numerous original papers published in reputable journals, reflecting his dedication to advancing our understanding of the brain and nervous system.
