报告人
Bo Hong Ph.D.
Professor, School of Biomedical Engineering
Investigator, McGovern Institute for Brain Research
Tsinghua University
Dr. Bo Hong received his Ph.D. degree of Biomedical Engineering from Tsinghua University in 2001. From 2004 to 2005, he was a visiting scientist in the Department of Biomedical Engineering and the Center for Neural Engineering at Johns Hopkins University, USA. He is now professor with School of Biomedical Engineering, Tsinghua University, and an investigator of McGovern Institute for Brain Research at Tsinghua. His main research interests are brain computer interface and language network in human brain, with publications on Nature Neuroscience, PNAS, Nature Communications, Journal of Neuroscience etc. His team developed minimally invasive epidural BCI - NEO system and successfully conducted implantation in 3 patients with spinal cord injury, with the first patient using the NEO BCI safely for more than one year at home.
报告信息
主持人：
崔翯博士
报告时间：
2024年11月13日
15:00-16:00
报告地点：
北京脑科学与类脑研究所
二期X102报告厅
报告语言：
英语
报告摘要
Reclaiming Hand Functions after Complete Spinal Cord Injury with Epidural Brain-Computer Interface
Spinal cord injuries significantly impair patients' ability to perform daily activities independently. While cortically implanted brain-computer interfaces (BCIs) offer high communication bandwidth to assist and rehabilitate these patients, their invasiveness and long-term stability limits broader adoption. We developed a minimally invasive BCI with 8 chronic epidural electrodes above primary sensorimotor cortex to restore hand functions of tetraplegia patients. With wireless powering and neural data transmission, this system enables real-time BCI control of hand movements and hand function rehabilitation in home use. A complete spinal cord injury (SCI) patient with paralyzed hand functions was recruited in this study. Over a 9-month period of home use, the patient achieved an average grasping detection F1-score of 0.91, and a 100% success rate in object transfer tests, with this minimally invasive BCI and a wearable exoskeleton hand. This system allowed the patient to perform eating, drinking and other daily tasks involving hand functions. Additionally, the patient showed substantial neurological recovery through consecutive BCI training, regaining the ability to hold objects without BCI. The patient exhibited a 5-point improvement in upper limb motor scores and a 27-point increase in the action research arm test (ARAT). A maximal increase of 12.2 μV was observed in the peak of somatosensory evoked potential, which points to a considerable recovery in impaired spinal cord connections. As of this month, three SCI patients has been implanted with NEO BCI and hand function rehabilitation is expected.
