报告人
HUANG, Z. Josh
Duke School of Medicine Distinguished Professor in Neuroscience
Department of Neurobiology
Duke University School of Medicine
Professor of Biomedical Engineering
Duke Pratt School of Engineering
Genetic dissection of cortical
neuron type trajectories:
fromdevelopmental origin
to behavioral function
主持人：
李冲博士
报告时间：
2024年11月4日
10:00-11:00
报告地点：
北京脑科学与类脑研究所
二期X102报告厅
报告语言：
英语
报告摘要
Genetic dissection of cortical neuron type trajectories: from developmental origin to behavioral function
The vast neural circuits of the cerebral cortex underlying high-level brain functions are built from a set of basic circuit templates shared by individuals of the species and conserved across mammalian evolution. To a great extent, cortical circuits self-assemble during development guided by information in genome and are then individually customized through learning and experience. A key challenge in understanding cortical circuitry is deciphering the nature and organization principle of the diversity of glutamatergic projection neuron (PN) “types” which, through their elaborate long axons, mediate the myriad cortical processing streams and output channels. Meeting this challenge requires strategies and methods to integrate multi-modal PN phenotypes and track their multi-faceted developmental trajectories, from origin in neural progenitors to circuit elements in behavior. In this seminar, I will highlight our progress in 1) building genetic tools, including the recent RNA-programmable CellREADR technology, to systematically dissect and fate map PN types and their progenitors; 2) exploring the role of direct and indirect neurogenesis mediated by radial glia and intermediate progenitors, respectively, in the specification and laminar deployment of distinct PN types; and 3) studying the function of genetic- and projection-defined PN types in skilled motor control. We aim to integrate the developmental genetic, systems neuroscience, and evolutionary explanations of PN diversity and organization that shape cortical circuit architecture.
Z. Josh Huang is Duke School of Medicine Distinguished Professor of Neuroscience in the Department of Neurobiology at Duke University. Previously he was Charles and Marie Robertson Professor of Neuroscience at the Cold Spring Harbor Laboratory. He received his undergraduate degree in Biology at FuDan University in Shanghai, his PhD in Molecular Biology with Michael Rosbash at Brandeis University, and his postdoctoral training with Susumu Tonegawa at the Massachusetts Institute of Technology. The overarching theme of Dr. Huang’s research is to understand the general principles of the development and function of neural circuits of the cerebral cortex. He is the recipient of a NIH Director’s Pioneer Award, McKnight Scholar Award in Neuroscience, a Pew Scholar Award, and is a member of American Academy of Arts and Sciences.
