近年来，Angewandte Chemie 及其所有者—德国化学学会（GDCh）主办的Angewandte Symposia 系列研讨会在全球范围内取得了巨大的成功。Angewandte Symposia 邀请世界顶尖的化学家作为主讲人，为 Angewandte Chemie 的作者与读者们带来精彩的主题演讲。
为了给 Angewandte Chemie 与化学研究者社群，尤其是年轻科研工作者们提供更多面对面交流的机会以及更好的支持不同事业阶段的化学研究者，Angewandte Chemie 组织了一系列 Angewandte Advances 研讨会。
Angewandte Advances 系列研讨会将作为大型化学学术会议的特别分会场，举行为期半天至一天的学术报告与讨论活动。每期 Angewandte Advances 将邀请来自不同领域、处于不同事业阶段的6-8位优秀学者做学术报告，并由Angewandte Chemie 的编辑主持以及组织讨论。
迄今为止，Angewandte Advances已经成功举办 13 届，我们期待为大家带来更多精彩的线下研讨会和交流平台。
第14届 Angewandte Advances 研讨会将作为11th Asian Biological Inorganic Chemistry Conference的特别分会场，于2024年12月2日在桂林漓江大瀑布饭店红梅厅(Hongmei Hall 3F)举办。
本期Angewandte Advances邀请到八位主讲人，分别为郭子建院士（南京大学），Kallol Ray教授（Humboldt-Universität zu Berlin），袁荃教授（武汉大学）， Maria Babak博士（City University of Hong Kong），陈春英院士（国家纳米科学中心），Wonwoo Nam教授（Ewha Womans University），刘志博教授（北京大学）和邹滔滔教授（中山大学），敬请期待！
会议日程
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主讲人及报告简介
郭子建 院士
南京大学
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Zijian Guo received his PhD degree from the University of Padua in 1994, and worked as a postdoc fellow and a research associate at the University of London and the University of Edinburgh successively. He joined Nanjing University in 1999 and served as the director of the State Key Laboratory of Coordination Chemistry from 2000 to 2009 and the dean of the School of Chemistry and Chemical Engineering from 2006 to 2014. He is currently the Chair of the Academic Committee of Nanjing University, a member of the Chinese Academy of Sciences (CAS) and a fellow of the Third World Academy of Sciences (TWAS). His research focuses on the chemical biology of metals and metallodrugs including the metal-based anticancer complexes and their targeted delivery, the fluorescent sensors for bio-metals, and the role of metals in immunology. He serves as editorial/advisory board members of several international journals, and was appointed as the editor-in-chief of Chemical & Biomedical Engineering, a new journal jointed launched by the American Chemical Society and Nanjing University in 2022. He was the winner of the Luigi Sacconi Medal of Italian Chemical Society in 2016 and the Outstanding Achievement Award of Asian Society of Biological Inorganic Chemistry in 2020.
报告题目：
Revisiting Platinum Anticancer Drugs in the Context of Immuno-Regulations
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Platinum-based anticancer drugs play an important role in the treatment of various malignancies such as colorectal and testicular cancers. However, drug resistance and side effects are challenging problems that hinder their wider clinical applications. Chemical biology approaches could be applied for elucidating the mechanism of action of different platinum anticancer drugs, and provides important tools for understanding the biological effects of platinum anticancer complexes in cellular energy conversion, metabolism and immune regulations.
In this lecture, I will focus on the molecular design of platinum-based antitumor complexes with multi-functional groups. We designed a class of platinum-based chemotherapeutic prodrugs which could be reduced in tumours via radiolysis. The combination of chemotherapy and immunotherapy in one molecule offers potential superiority for the solid tumor models. These results demonstrated that in addition to DNA binding, bio-energetic pathways may also play crucial roles in manipulating the tumor microenvironments.
Prof. Kallol Ray
Humboldt-Universität zu Berlin
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Kallol Ray received his PhD degree from the University of Bochum and Max-Planck Institute (MPI) for Bioinorganic Chemistry (now MPI for Chemical Energy Conversion) in 2005, and worked as a postdoctoral fellow at the University of Minnesota. He joined the department of chemistry at the Humboldt-Universität zu Berlin in 2009, where he is presently a Full Professor of Inorganic Reaction Mechanism and Spectroscopy. His work investigates the role of metal ions in biological systems and their interactions with small molecules like dioxygen and carbon dioxide, thereby, contributing to advancements in understanding metal-dependent enzymes and their mechanisms. Dr. Ray serves as the executive board member of the Einstein centre of catalysis (EC2), and also acts as one of the research coordinators of the cluster of excellence, Unifying Systems in Catalysis (UniSysCat). He worked in the management committee of the European COST Action Network “Explicit Control Over Spin-states in Technology and Biochemistry (ECOSTBio)”, which fosters scientific cooperation across Europe in the areas of chemistry and materials science. Dr Ray’s research, which focus on bridging the gap between fundamental science and practical applications, has been recognized with various awards like the Silver Medal of the European Bioinorganic Chemical Society (2020), the Ernst–Haage Award in the field of bioinorganic chemistry and catalysis, the Wöhler–EurJIC Young Investigator Prize (2013), and the Carl Duisberg Memorial Award (2015).
报告题目：
Small Molecule Activiation at Transition Metal Centers: Stucture-Function Correalations
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Small molecule activation constitutes one of the main frontiers of inorganic and organometallic chemistry, with much effort directed towards the development of new processes for the selective and sustainable transformation of abundant small molecules such as dioxygen (O2), water (H2O), hydrogen peroxide (H2O2) or protons (H+) into high-value chemical feedstocks and energy resources. Because nature mostly uses metal ions to activate these relatively inert molecules and modulate their reactivity, much inspiration for the field has come from bioinorganic chemistry. This talk will focus on some of the recent highlights from our group on homogenously catalyzed bioinspired activation of small molecules, as well as stoichiometric reactions that further our understanding towards such ends. It will cover many aspects of small molecule activation including: organometallic chemistry, spectroscopy, synthesis, and detailed mechanistic studies involving trapping of reactive intermediates. The demonstrated examples will help to emphasize the continuous effort of our group in uncovering the structure-reactivity relationships of biomimetic model complexes, which may allow vital insights into the prerequisites necessary for the design of efficient catalysts for the selective functionalization of unactivated C–H bonds, O2/H2O/H2O2 activations, or H+ reductions by using cheap and readily available first-row transition metals under ambient conditions.
袁荃 教授
武汉大学
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Dr. Quan Yuan is a full professor at Wuhan University in China. She received her BS degree from Wuhan University in 2004 and PhD degree from Peking University in 2009. Later, she continued her postdoctoral research in University of Florida. Dr. Yuan’s group focuses on analysis of complex biological samples. Dr. Yuan has authored over 190 high-quality papers and has received many academic awards including: the Science and Technology Award for Chinese Youth in 2022, the Xplorer prize in 2021, the National Science Fund for Distinguished Young Scholars in 2019, Periodic Table of Younger Chemist by IUPAC in 2019, Nano Research Young Innovators Award in 2018, etc.
报告题目：
Design of Aptamer-based Molecular for Bioanalysis and Biomedical Application
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DNA aptamers refer to nucleic acid species that have been engineered through systematic evolution of ligands by exponential enrichment (SELEX) to bind to various molecular targets. The nanostructure of DNA aptamers can be easily transformed through hybridizing with complementary strands, and the aptamers can realize reproducible transformation of its nanostructure at a high temperature and high salt concentration. These features make DNA aptamers a powerful tool in the field of chemical and biological analysis. However, the limited chemical functionality of nucleobases can lead to the paucity of nanostructures and functions in a natural nucleic acid library. The chemical capability to synthesize artificial nucleotides can expand the chemical space of nucleic acid libraries and further increase the functional diversity of nucleic acids. In view of this situation, we developed an artificial-nucleotide-expanded cell SELEX method for modular expansion of the chemical space of nucleic acid libraries. Using this strategy, we have discovered a series of functional nucleic acid aptamers those can regulate the protein-protein interaction of target proteins and can be used in drug design. This chemical design assisted in vitro selection approach enable the generation of a new class of functional nucleic acids for elucidating the molecular basis of biological activities and uncovering new design of protein-inhibitor pharmaceuticals.
Dr. Maria Babak
City University of Hong Kong
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Dr. Maria Babak serves as an assistant professor at the City University of Hong Kong and leads the Drug Discovery Lab there. She ranks among the top 2% of the most cited researchers globally, as per the Stanford/Elsevier ranking. In 2022, she received the prestigious Graeme Hanson-AsBIC Early Career Award, recognizing her contributions as an early career researcher in the Asia Pacific region, particularly in the realm of biological inorganic chemistry. Further, in 2024, Dr. Babak received the Yvonne Award, celebrating emerging leaders in cancer care. Her research spans the interdisciplinary domains of chemistry, biology, and medicine, with a primary focus on discovering and advancing preclinical development of anticancer therapies for resistant and aggressive cancers lacking effective treatment options. Additionally, she directs efforts towards innovating detection methods for counterfeit anticancer medications. Dr. Babak actively contributes as a board member of the Institute of Cancer and Crisis, dedicated to alleviating the challenges faced by cancer patients during crises.
报告题目：
The Gut Factor: The insights into the Mechanism of Action of Anticancer Gold complexes
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Even though the role of microbiome in cancer has only recently been discovered, it is evident that microbiome research holds a great promise for cancer treatment. While the immediate impact may be limited by the complexities of translating in vitro findings to clinical applications, the long-term implications suggest the potential for tailored microbiome-based therapies, thereby introducing more accurate and efficient strategies for individuals with cancer. In this presentation, we for the first time will demonstrate that despite the multifactorial nature of the microbiome, manipulating its composition can serve as a viable therapeutic avenue for drug development through screening and design strategies.
陈春英 院士
国家纳米科学中心
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Chunying Chen, Academician of Chinese Academy of Sciences, New Cornerstone Investigator, Deputy Director of CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, Professor in National Center for Nanoscience and Technology, China.
Her research interests including the analysis of nanoprotein corona, important biological effects such as stealth effect, far-reaching effect and transport-transformation-bioavailability chain, which has guided the application research of nanoadjuvants and drug delivery systems. She has published over 400 peer-reviewed articles including Nature Nanotechnology, Nature Methods, Nature Protocols, Nature Communications, Science Advances, PNAS, JACS and Angew Chem. she has received numerous awards, including the Second Prize of the National Natural Science Award, National May Day Female Pacesetter, IUPAC Distinguished Women in Chemistry or Chemical Engineering, TWAS Chemistry Award, RSC Environment Prize, ACS Bioconjugate Chemistry Lectureship award, Chinese Young Female Scientists Award. She is currently an Executive Editor of ACS Nano and editorial board members of several journals.
报告题目：
Metalloimmunology: Immune Regulations by Metal-based Nanoparticles for Vaccine Enhancement
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In recent years, metal-based nanoparticles based on metalloimmunology have attracted tremendous attentions in biomedical fields due to their excellent efficacy. Variety of metallic nanomaterials and different metal oxide/sulfide/nitride nanostructures can help realize targeted delivery of the metal ions and the synergistic theranostics. The activation of the stimulator of interferon gene (STING) pathway is considered as the most potent approach for reprogramming the immunosuppressive tumour-associated myeloid cells within the TME, inducing an antitumour adaptive immune response and increasing the immunogenicity of tumours. Various types of STING agonists, such as modified cyclic dinucleotides, polymers, synthetic small-molecule agonists and metal ions (Mn2+ and Zn2+), have been reported to efficiently activate STING. Recent studies have shown that Mn2+ ions have emerged as a STING agonist with clinical potential. The dynamics of intracellular release or exchange of metal ions from nanomaterials following their cellular internalization are also discussed. This talk also highlight the powerful performance of nanoadjuvants in vaccine development against virus infection.
Prof. Wonwoo Nam
Ewha Womans University
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Wonwoo Nam received his B.S. (Honors) degree in Chemistry from California State University, Los Angeles in 1985 and his Ph.D. degree in Inorganic Chemistry from UCLA under the direction of Professor Joan S. Valentine in 1990. After one year postdoctoral experience at UCLA, he became an Assistant Professor at Hong Ik University in 1991. He moved to Ewha Womans University in 1994, where he is currently a Distinguished Professor of Ewha Womans University. His research interests are (1) biomimetic studies of heme and nonheme iron enzymes, such as the synthesis and spectroscopic and structural characterization of heme and nonheme iron-oxygen intermediates in dioxygen activation chemistry by biomimetic compounds, (2) water oxidation & artificial Photosystem II, such as the elucidation of the mechanism of O-O bond formation using metal-oxygen intermediates, and (3) bioinspired catalytic asymmetric oxidation reactions, such as the development of efficient asymmetric oxidation reactions using synthetic biomimetic catalysts and understanding of their reaction mechanisms. He has published more than 430 papers, including Science (2), Nature (1), Nature Chemistry (4), Accounts of Chemical Research (6), Journal of the American Chemical Society (JACS, 102), Angewandte Chemie International Edition (ACIE, 30), and Chemical Science (17).
报告题目：
Biomimetic Metal-Oxygen Intermediates in Dioxygen Activation Chemistry
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Dioxygen is essential in life processes, and enzymes activate dioxygen to carry out a variety of biological reactions. One primary goal in biomimetic research is to elucidate structures of reactive intermediates and mechanistic details of dioxygen activation and oxygenation reactions occurring at the active sites of enzymes, by utilizing synthetic metal-oxygen complexes. A growing class of metal-oxygen complexes, such as metal–superoxo, –peroxo, –hydroperoxo, and –oxo species, have been isolated, characterized spectroscopically, and investigated in various oxygenation reactions. During the past decade, we have been studying the chemical and physical properties of various reactive intermediates in oxygenation reactions, such as high-valent iron(IV)- and manganes(V)-oxo complexes of heme and non-heme ligands in oxo-transfer and C-H activation reactions, non-heme metal-peroxo complexes in nucleophilic reactions, and non-heme metal-superoxo complexes in electrophilic reactions. The effects of supporting and axial ligands on structural and spectroscopic properties and reactivities of metal-oxygen adducts have been extensively investigated as well. In this presentation, I will present our recent results on the synthesis and structural and spectroscopic characterization of mononuclear nonheme metal-dioxygen intermediates as well as their reactivities in electrophilic and nucleophilic oxidation reactions.
刘志博 教授
北京大学
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Zhibo Liu is a full professor in the College of Chemistry and Molecular Engineering at Peking University, with joint appointments in PKU-THU Centre for Life Sciences and Changping Laboratory. He received his B.S. in Chemistry from Nanjing University in 2010 and Ph.D. in Radiopharmaceutical Chemistry from the University of British Columbia in 2014. After postdoctoral training at the National Institutes of Health, he joined Peking University in 2016 as the Principal Investigator of the Laboratory of Radiochemical Biology and Radiopharmaceuticals. His research interests include 1) In vivo cleavage chemistry; 2) Radiopharmaceuticals and boron neutron capture therapy; and 3) Radiotherapy-activated prodrugs. Several radiopharmaceuticals he developed are in the clinical stage or have received IND from CDE or FDA. He has received the XPLORER prize, the honors of the National Science Fund for Distinguished Young Scholars, the Young Scholar Award (Chinese Chemistry Society), the Teaching Excellence Award (Peking University), etc.
报告题目：
Probing and Perturbing: Cancer Theranostics with Radioactivity
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Radiopharmaceuticals are heating the global pharmaceutical markets, with eight of the top ten multinational corporations already investing in this field. Its development necessitates interdisciplinary collaboration. China has previously faced bottlenecks in the radiopharmaceuticals field, with an urgent need for fundamental innovation in drug research. So, what exactly is radiopharmaceuticals, and how can we excel in its development? Additionally, since the discovery of ionized radiation, it has been applied in clinical diagnostics and treatments, mainly by leveraging the unique biological effects of radiation in the body. This raises the question: can ionized radiation regulate chemical reactions in living organisms, thereby controlling drug release or protein activation? To address these issues, our team has successfully produced medical isotopes like Ac-225 for the first time in China and has reported the radiotherapy-activated prodrugs to reduce the systematic toxicity of cancer therapy. We introduced a novel concept of targeted covalent radioligands to overcome the longstanding challenge of insufficient targeting in the field. Several nuclear medicine compounds developed by our team are now undergoing clinical trials.
邹滔滔 教授
中山大学
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Taotao Zou is a professor in School of Pharmaceutical Sciences of Sun Yat-Sen University. He obtained the bachelor degree in chemistry from Wuhan University, and PhD from The University of Hong Kong (HKU) under the supervision of Professor Chi-Ming Che. After that, he has been a postdoc fellow at the University of Warwick with Prof. Peter J Sadler, at HKU with Prof. Chi-Ming Che, and at The Scripps Research Institute with Profs. Xiang-Lei Yang and Paul Schimmel. Taotao was an Assistant Professor in School of Science and Engineering of The Chinese Unviersity of Hong Kong, Shenzhen during Mar 2018 to Jul 2018, and he has been a full professor in School of Pharmaceutical Sciences of Sun Yat-sen University since Jul 2018. His research interests lie at the interface of chemistry and biology, particularly, medicinal chemistry and chemical biology of metal complexes, including anti-cancer compounds with in vitro and in vivo activities, immunogenic cell death inducers, drug target identification. His research has been recognized by local and international awards, such as Graeme Hanson Early Career Award, CAS Future Leaders, Li Ka Shing Prizes etc.
报告题目：
Modulating the Chemical Reactivity of Gold Complexes in Living Systems: From Concept to Anticancer Treatment
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Over the past few decades, research on the chemistry of gold has progressed rapidly, encompassing topics like catalysis, supramolecular chemistry, molecular recognition, etc. These chemical properties are of great value in developing therapeutics or orthogonal catalysts in biology. However, the presence of concentrated nucleophiles and reductants, particularly thiol-containing serum albumin in blood and glutathione (GSH) inside cells that can strongly bind and quench the active gold species, makes it difficult to translate the chemistry of gold from test tubes into living systems. In this regard, modulating the chemical reactivity of gold complexes to conquer nonspecific interactions with thiols and meanwhile to controllably activate their reactivity in a spatiotemporal manner is of pivotal importance to develop gold complexes for biomedical applications. In this talk, the concept of developing stimuli-activatable gold complexes will be highlighted, with several recently developed examples. These complexes display masked chemical properties, the bioactivity of which can be spatiotemporally activated at the target site by leveraging approaches from classic structure design to recently emerged photo- and bioorthogonal-activation. (References: Acc. Chem. Res. 2023, 56, 1043-1056; J. Am. Chem. Soc. 2024, 146, 8547-8556)
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