完整议程全公开!《药海共潮 创新共舞——2024国际药物研发论坛》重磅来袭!

健康   2024-11-18 17:36   重庆  

随着社会经济的发展和人民生活水平的提高,人们对健康的需求也不断增加,医药行业作为满足人们健康需求的重要产业,其可持续发展面临着诸多挑战和机遇。可持续发展要求不断创新,医药行业在创新药物研发方面也面临着巨大压力和机遇。
为进一步加强生物药物创新技术交流,打通“基础研究-新药创制-成果转化”三大环节之间的壁垒,努力建设新药创制生态圈,推动世界新药创制事业的源头创新、持续创新和循环创新。
由北京市昌平区人民政府,北京市科学技术管理委员会、中关村科技园区管理委员会,未来科学城管理委员会(生命园管委会),北京市昌平区科学技术委员会指导,北京中关村生命科学园发展有限责任公司,Nature-Portfolio,北京昌平科技园发展集团有限公司主办的“2024国际药物研发论坛”将于2024年11月22日(周五)在北京九华山庄会展酒店举行。
本届会议邀请国内外行业专家与业界精英齐聚一堂,围绕生物药研发新技术、药物开发实践和行业未满足的临床需求等问题,为行业搭建交流合作平台。

预计阅读时间:29分钟

01

会议信息

论坛名称:自然合作会议:2024国际药物研发论坛

会议时间:2024年11月22日

会议地址:北京市昌平区九华山庄会展酒店(16区)3层101、102

指导单位:

北京市昌平区人民政府

北京市科学技术管理委员会、中关村科技园区管理委员会

未来科学城管理委员会(生命园管委会)

北京市昌平区科学技术委员会

主办单位:

北京中关村生命科学园发展有限责任公司

Nature-Portfolio

北京昌平科技园发展集团有限公司

02

会议议程

03

出席大咖

罗敏敏

1973年出生于江西省上高县,神经生物学家,北京脑科学与类脑研究中心联合所长主任、新基石研究员 。

罗敏敏于1995年从北京大学毕业,之后赴美国留学;1997年获得美国宾夕法尼亚大学计算机科学硕士学位;2000年获得宾夕法尼亚大学神经学博士学位;2000年至2004年在杜克大学神经生物学系从事博士后研究工作;2004年回到中国后长期在北京生命科学研究所担任研究员;2005年获得国家杰出青年科学基金资助;2018年兼任北京脑科学与类脑研究所所长;2023年获得首期新基石研究员项目资助。

LUO Minmin

Born Jiangxi Province, LUO Minmin is a neurobiologist and serves as the Director of the Chinese Institute for Brain Research, Beijing (CIBR) and a New Cornerstone Investigator. He graduated with a BS degree in psychology from Peking University in 1995 and then went to the United States for further studies; he obtained a Master's degree in Computer Science from the University of Pennsylvania in 1997 and a Ph.D. in Neuroscience from the same university in 2000. From 2000 to 2004, he conducted postdoctoral research at HHMI and the Department of Neurobiology at Duke University. After returning to China in 2004, he has long served as an Investigator at the National Institute of Biological Sciences, Beijing. In 2005, he was awarded funding from the National Natural Science Fund for Distinguished Young Scholars. In 2018, he took on the additional role of Director of CIBR.

Adil Mardinoglu 

Adil Mardinoglu 教授是英国伦敦国王学院宿主与微生物组相互作用中心和瑞典皇家理工学院生命科学实验室(SciLifeLab)的系统生物学教授。Mardinoglu 教授领导着一个由30余人组成的研究团队,将多组学、系统生物学、人工智能和实验生物学与药物开发相结合,领导开发针对代谢性疾病、神经退行性疾病以及某些癌症的新型治疗策略。

作为瑞典人类蛋白质图谱计划的主要贡献者,Mardinoglu 教授协助构建了全面的人类组织、亚细胞和病理学图谱,并在国际人类细胞图谱计划中协助开发了细胞图谱。他的学术成果包括在Science, Nature, Nature Biotechnology, Cell Metabolism, Nature Metabolism, Nature Communications, PNAS, Cell Reports, Molecular Systems Biology,和EbioMedicine等杂志上发表的超250篇原创研究和综述。此外,作为 SZA Longevity、BASH Biotech、ScandiBio Therapeutics、ScandiEdge Therapeutics 和 Trustlife Therapeutics 的联合创始人,他为生物技术领域做出了巨大的创业贡献。

Adil Mardinoglu Bio

Professor Adil Mardinoglu works as a Professor of Systems Biology at the Centre for Host-Microbiome Interactions at King’s College London, UK, and Science for Life Laboratory (SciLifeLab) at KTH-Royal Institute of Technology in Sweden. At the helm of a 30-strong research team, Professor Mardinoglu spearheads the development of novel treatment strategies for metabolic and neurodegenerative diseases, as well as certain cancers, blending multiomics, systems biology, AI and experimental biology with drug development.

A key contributor to the Swedish Human Protein Atlas program, Professor Mardinoglu has aided in the construction of a comprehensive human tissue, subcellular, and pathology atlas, and he has been instrumental in developing the cell atlas within the international Human Cell Atlas initiative. His scholarly output includes around more than 250 research and review articles published in journals such as Science, Nature, Nature Biotechnology, Cell Metabolism, Nature Metabolism, Nature Communications, PNAS, Cell Reports, Molecular Systems Biology, and EbioMedicine. Furthermore, as a co-founder of SZA Longevity, BASH Biotech, ScandiBio Therapeutics, ScandiEdge Therapeutics, and Trustlife Therapeutics, he has made substantial entrepreneurial contributions to the biotech sector.

帅克

南京大学现代生物研究院终身正教授,博导
国家创新长期项目海外高层次引进人才
美国加州大学洛杉矶分校(UCLA)终身荣誉教授(Professor Emeritus)

天汇资本原创新药投资首席科学家

帅克教授于1990年在美国艾伯特爱因斯坦医学院(Albert Einstein College of Medicine)取得博士学位,随即进入美国洛克菲勒大学师从世界著名的荣获美国总统科学奖章的James E. Darnell教授实验室进行博士后研究。1994年入职美国加州大学洛杉矶分校(UCLA),并于2004年成为UCLA终身正教授。2021年7月,帅克教授辞去其长期任教的UCLA终身正教授职位,全职加盟南京大学现代生物研究院。

帅克教授是著名的JAK-STAT 信号传导通路的主要发现人之一。他在世界上首次发现干扰素信号调控中一个重要蛋白质是具有特异DNA识别功能的转录因子 (Shuai et al., 1992, Science),并将其正式命名为STAT (Signal Transducer and Activator of Transcription) (Shuai et al., 1993, Science), 及STAT/JAK信号通路 (Shuai et al., 1993, Nature; Shuai et al., 1994, Cell)。他的实验室首先发现并命名了PIAS (Protein Inhibitor of Activated STAT) 家族蛋白 (Chung et al., 1997, Science; Liu et al., 2007, Cell; Liu et al., 2010, Science),证明了PIAS为重要的STAT调控因子。这些重大发现为临床治疗和药物开发提供了崭新的途径。帅克教授的研究成果发表在Cell、Nature、Science等国际顶尖期刊。近年来,多个靶向JAK-STAT信号通路的创新型药物已经被广泛用于多种自身性免疫疾病的治疗中。JAK抑制剂在肿瘤免疫治疗的临床II期研究取得了积极的进展。以帅克教授为发明人之一的一项JAK-STAT专利被成功用于治疗再生障碍性贫血病的药物 Promacta (艾曲波帕) 的开发。诺华(Novartis)的Promacta药物在2021年的年度销售额就已经超过20亿美元。

Ke Shuai, Ph.D.

Full Professor with Tenure at the Institute of Modern Biology, Nanjing University

Overseas High-Level Talent of the National Innovation Long-Term Program

Professor Emeritus at the University of California, Los Angeles (UCLA)

Chief Scientist of Innovative Drug Investment at Tianhui Capital

Professor Shuai obtained his Ph.D. in 1990 from the Albert Einstein College of Medicine in the United States. He then began his postdoctoral research at Rockefeller University, working in the lab of Professor James E. Darnell, a world-renowned scientist and recipient of the U.S. Presidential Science Medal. In 1994, Professor Shuai joined the University of California, Los Angeles (UCLA), and in 2004, he became a full professor with tenure at UCLA. In July 2021, he resigned from his long-held tenured position at UCLA to join the Institute of Modern Biology at Nanjing University full-time.

Professor Shuai is one of the primary discoverers of the JAK-STAT signaling pathway. He was the first in the world to identify that an important protein in interferon signaling is a transcription factor with specific DNA recognition functions (Shuai et al., 1992, Science), which was later named as STAT (Signal Transducer and Activator of Transcription) (Shuai et al., 1993, Science), and the STAT/JAK signaling pathway (Shuai et al., 1993, Nature; Shuai et al., 1994, Cell). His laboratory was the first to discover and name the PIAS (Protein Inhibitor of Activated STAT) family of proteins (Chung et al., 1997, Science; Liu et al., 2007, Cell; Liu et al., 2010, Science), demonstrating that PIAS proteins are key regulators of STATs. These groundbreaking discoveries have provided new avenues for clinical treatment and drug development. Professor Shuai's research has been published in leading international journals such as Cell, Nature, and Science. In recent years, innovative drugs targeting the JAK-STAT signaling pathway have been widely used to treat various autoimmune diseases. JAK inhibitors have shown promising results in Phase II clinical trials for tumor immunotherapy. A patent on JAK-STAT signaling, with Professor Shuai as one of the inventors, was successfully used in the development of the drug Promacta (Eltrombopag) for treating aplastic anemia. Novartis' Promacta had annual sales exceeding $2 billion in 2021.

Minoru Takasato 博士

理化学研究所生物系统动力学研究中心团队负责人

Minoru Takasato博士是人类多能干细胞定向分化为肾脏的专家,所在实验室专注于重现人类器官发生过程,利用人类多能干细胞生成类器官,在Nature,Nature Methods,Nature Communications,Nature Cell Biology,Cell Stem Cell 等高水平期刊发表多篇论文。

Minoru Takasato Ph.D.

Team leader at RIKEN BDR, Kobe Japan

Dr. Minoru Takasato is an expert in the directed differentiation of human pluripotent stem cells into kidneys. His laboratory focuses on reproducing the process of human organogenesis, using human pluripotent stem cells to generate organoids. In Nature, Published multiple papers in high-level journals such as Nature Methods, Nature Communications, Nature Cell Biology, Cell Stem Cell, et.

张曼博士

2022年加入英矽智能任副总裁,生物与转化医学负责人。她在药物发现和转化医学研究方面拥有超过15年的经验。2008年至2016年,张博士在诺华上海公司担任职能和项目负责人,领导多个肿瘤、慢性肝病发现项目。随后,她加入杨森上海研发中心乙肝研发部,领导多个抗乙肝研发项目。在恒瑞医药,她建立了转化医学团队,支持多个资产的早期临床开发,包括IND授权、生物标志物发现、适应症扩展和药物组合等。张博士在中国北京大学生命科学学院获得理学学士和硕士学位,并在美国德克萨斯大学奥斯汀分校获得博士学位。

Dr. Man (Maya) Zhang

joined Insilico Medicine in 2022 as VP, Head of biology and translational medicine, leading discovery biology and translational medical research. Dr. Zhang has more than 15 years’ working experience in pharmaceutical and biotechnology companies. In 2008 to 2016, Dr. Zhang worked as a function and project leader at Novartis Shanghai site, leading multiple oncology, chronical liver diseases discovery projects. She then joined Hepatitis B DAS in Janssen Shanghai Discovery Center, leading multiple anti-hepatitis B discovery projects. In Hengrui Pharmaceutical, she has established a translational medicine team to support early clinical development of multiple assets including IND enabling, biomarker discovery, indication expansion and drug combination etc. Dr. Zhang obtained Bachelor of Science and Master of Science from the School of Life Sciences of Peking University, China and PhD from the University of Texas at Austin, USA.

Bernd Wollscheid

Bernd Wollscheid博士是DISCO Pharmaceutical的创始人。他同时是瑞士苏黎世联邦理工学院分子健康教授及转化医学研究所所长。他担任ETH领域战略重点项目“个性化健康与相关技术(PHRT)”的执行委员会主席,致力于将科学发现应用于医疗保健实践。Bernd的研究团队在生物学、化学、医学和生物信息学交叉领域,率先开发并应用下一代技术。这些研究有助于理解分子纳米级结构如何影响细胞功能,并为治疗性诊断开辟了新机遇。

Bernd曾在德国弗莱堡马克斯-普朗克免疫生物学研究所学习化学,并获得分子免疫学博士学位。他曾在美国西雅图系统生物学研究所从事博士后研究。

Bernd Wollscheid

Bernd Wollscheid, Ph.D., is founder of DISCO Pharmaceuticals. He is a Professor of Molecular Health and Head of the Institute of Translational Medicine at the Department of Health Sciences and Technology at ETH Zürich, Switzerland. As the chairman of EC of the ETH domain Strategic Focus Area, “Personalized Health and Related Technology (PHRT),” he aims to bridge the gap between scientific discoveries and their practical applications in healthcare. Bernd’s research team pioneers developing and applying next-generation technologies at the intersection of biology, chemistry, medicine, and bioinformatics. This research contributes to understanding how molecular nanoscale organization influences cellular function and opens up new opportunities for theranostics.

Bernd studied Chemistry and holds a Ph.D. in Molecular Immunology from the Max Planck Institute of Immunobiology in Freiburg, Germany. He performed post-doctoral research at the Institute of Systems Biology, Seattle, USA.

王军

王军,理学博士

中国科学院微生物研究所,中科院免疫与病原微生物重点实验室

德国马普学会合作伙伴小组-生物信息学与计算生物学研究组长,研究员

主要研究方向: 生物信息学和计算生物学分析;微生物大数据的比较和挖掘;新测序方法和人工智能方法的应用。

人体微生物组是指人体内由微生物组成的共生生态群落。近年来,人体微生物组受到生命科学和医学研究领域的高度关注,复杂的微生物组参与人体各系统生理功能,而菌群异常可导致多种疾病,包括感染、代谢性疾病以及自身免疫疾病等。申请人关注微生物组研究领域的核心问题——如何高效、准确鉴定和利用微生物组中影响人类健康与疾病的关键类群以及作用分子,主要研究成果包括:1)在感染性疾病研究中,建立了快速而精准的靶向RNA的病原检测方法;使用人工智能方法高通量发现了一系列微生物源新型抗菌多肽,用于耐药病原的治疗。2)在代谢相关研究中,结合三代测序产生的长读长序列信息,在菌株水平实现对微生物组代谢潜力的精细解析;通过对人体和模式动物肠道菌群节律的研究,发现并验证了影响宿主肠道节律和代谢的关键氨基酸。3)在自身免疫性疾病研究中,通过临床合作,发现了在免疫失调中微生物组发挥作用的关键“致病”蛋白组分,以及能够有效抑制自身免疫反应的微生物源“治病”蛋白成分。

Wang Jun, PhD in Science

Institute of Microbiology, Chinese Academy of Sciences, Key Laboratory of Immunology and Pathogenic Microorganisms, Chinese Academy of Sciences.

German Max Planck Society Partner Group - Bioinformatics and Computational Biology Research Leader, Researcher.

Main research areas: Bioinformatics and Computational Biology Analysis; Comparison and mining of microbial big data; The application of new sequencing methods and artificial intelligence methods.

The human microbiome refers to the symbiotic ecological community composed of microorganisms within the human body. In recent years, the human microbiome has received high attention in the fields of life sciences and medical research. The complex microbiome is involved in the physiological functions of various systems in the human body, and abnormal microbiota can lead to various diseases, including infections, metabolic diseases, and autoimmune diseases. The applicant pays attention to the core issue in the field of microbiome research - how to identify and use the key groups and action molecules in the microbiome that affect human health and disease efficiently and accurately. The main research achievements include: 1) In the research of infectious diseases, a rapid and accurate method for pathogen detection targeting RNA has been established; A series of novel antimicrobial peptides derived from microorganisms have been discovered through high-throughput artificial intelligence methods for the treatment of drug-resistant pathogens. 2) In metabolic related research, combining the long read long sequence information generated by third-generation sequencing, fine analysis of microbial metabolic potential can be achieved at the strain level; Through the study of gut microbiota rhythms in humans and model animals, key amino acids that affect host gut rhythms and metabolism have been identified and validated. 3) In the study of autoimmune diseases, through clinical collaboration, key "pathogenic" protein components that play a role in the microbiome in immune disorders have been discovered, as well as microbial derived "therapeutic" protein components that can effectively inhibit autoimmune responses.

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