医学新锐 | 欢迎朱少奇副教授加入中山大学医学院

朱少奇

中山大学医学院

副教授

博士生导师

基因表达的特异性是多细胞生物细胞分化和疾病发生的重要基础。基因的转录调控由转录因子通过驱动染色质表观特征（如染色质开放性、组蛋白修饰、染色质三维结构）的改变来实现。

本实验室基于表观基因组学（如ATAC-seq，RNA-seq）和染色质三维结构数据（如Hi-C），研究染色质表观特征的改变如何通过增强子-启动子相互作用等机制调控基因表达，并建立相应的定量模型，以揭示动物细胞发育分化和疾病发生的分子机制。

1，免疫CD8+T细胞激活过程中表观组学和染色质三维结构变化与基因表达调控的定量研究。

2，基于HiC大数据的染色质三维结构变化与基因转录调控的算法研究。开发HiCHub算法，寻找细胞特异性的染色质聚集性区域。

3，肿瘤，免疫和神经退行性疾病中DNA突变对染色质结构的影响以及与疾病表型的关系。

2012.09-2017.07 北京大学物理学院，凝聚态物理，理学博士

2008.09-2012.07 北京科技大学，应用物理学，理学学士

2024.11-至今 中山大学医学院，副教授

2023.10-2024.07 乔治华盛顿大学物理系，研究科学家

2019.07-2023.09 乔治华盛顿大学物理系，博士后

2017.07-2019.06 北京大学定量生物中心，博士后

1, Shaoqi Zhu#, Jia Liu#, Vanita Patel, Xiuyi Zhao, Weiqun Peng, Hai-Hui Xue. “Antigen exposure reshapes chromatin architecture in central memory CD8+ T cells and imprints enhanced recall capacity.” Proceedings of the National Academy of Sciences 120, no. 51 (2023): e2313476120. (IF: 11.1)

2, Qiang Shan#, Shaoqi Zhu# , Xia Chen, Jia Liu, Shuang Yuan, Xiang Li, Weiqun Peng, and Hai-Hui Xue. "Tcf1–CTCF cooperativity shapes genomic architecture to promote CD8+ T cell homeostasis." Nature Immunology 23, no. 8 (2022): 1222-1235. (IF: 31.25)

3, Jia Liu#, Shaoqi Zhu# , Wei Hu, Xin Zhao, Qiang Shan, Weiqun Peng, Hai-Hui Xue. "CTCF mediates CD8+ effector differentiation through dynamic redistribution and genomic reorganization." Journal of Experimental Medicine 220, no. 4 (2023): e20221288. (IF: 15.3)

4, Xin Zhao#, Wei Hu#, Sung Rye Park#, Shaoqi Zhu#, Shengen Shawn Hu, Chongzhi Zang, Weiqun Peng, Qiang Shan & Hai-Hui Xue. “The transcriptional cofactor Tle3 reciprocally controls effector and central memory CD8+ T cell fates.” Nature Immunology (2024): 1-13. (IF: 31.25)

5, Xiang Li#, Shuang Yuan#, Shaoqi Zhu#, Hai-Hui Xue, and Weiqun Peng. "HiCHub: A Network-Based Approach to Identify Domains of Differential Interactions from 3D Genome 2, Data." bioRxiv (2022).

6, Qiang Shan#, Shengen Shawn Hu#, Shaoqi Zhu, Xia Chen, Vladimir P. Badovinac, Weiqun Peng, Chongzhi Zang, and Hai-Hui Xue. "Tcf1 preprograms the mobilization of glycolysis in central memory CD8+ T cells during recall responses." Nature immunology 23, no. 3 (2022): 386-398. (IF: 31.25)

7, Xin Zhao, Shaoqi Zhu, Weiqun Peng, and Hai-Hui Xue. "The Interplay of Transcription and Genome Topology Programs T Cell Development and Differentiation." The Journal of Immunology 209, no. 12 (2022): 2269-2278. (IF: 4.4)

8, Qiang Shan#, Xiang Li#, Xia Chen, Zhouhao Zeng, Shaoqi Zhu, Kexin Gai, Weiqun Peng, and Hai-Hui Xue. "Tcf1 and Lef1 provide constant supervision to mature CD8+ T cell identity and function by organizing genomic architecture." Nature communications 12, no. 1 (2021): 1-20. (IF: 16.6)

9, Yixuan Li, Xiangyang Zhang, Shaoqi Zhu, Eden A. Dejene, Weiqun Peng, Antonia Sepulveda, and Edward Seto. "HDAC10 Regulates Cancer Stem-like Cell Properties in KRAS-driven Lung Adenocarcinoma." Cancer research 80, no. 16 (2020): 3265-3278. (IF: 11.2)

10, Shaoqi Zhu, Biao Wu, Roles of energy eigenstates and eigenvalues in equilibration of isolated quantum systems. Phys. Rev. E. 96.042124 (2017). (IF: 2.71)

11, Shaoqi Zhu, Biao Wu, Interaction effects on Wannier functions for bosons in an optical lattice. Phys. Rev. A 92,063637 (2015). (IF: 2.9)