在包括骨肉瘤在内的几种类型的肿瘤中已经观察到microRNA （miRNA）的失调。
2019 年 8 月 14 日，中国医科大学附属盛京医院的 He Ming 等人在 Aging (Albany NY) 杂志在线发表题为 “miR-627-3p inhibits osteosarcoma cell proliferation and metastasis by targeting PTN” 的研究论文，该研究表明，miR-627-3p可能是治疗骨肉瘤或预防转移的有用治疗靶点。
但是，在 2024 年 10 月 15 日，该文章被撤回，主要原因是多篇不同文章间涉嫌图像的重复使用。
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上述文章已被撤回，Aging 已经完成了对该文章的调查。对这篇论文提出了多种担忧，包括内部重复和与来自不同机构的不相关论文重叠。在图 4A-4D 和 5B、5F 的 Transwell 检测图像中发现了内部重复。杂志还发现，作者重复使用了早些时候发表在图 4A、4C、4D 和文章[1，2] 图5B 以及文章[3] 图 3G 和文章[4]图 5C 中的不相关实验的 Transwell 检测图像和蛋白质印迹图像；外部重复/重叠是来自不同机构的不相关文章，这些文章是在 2014 年至 2019 年 6 月期间，即相关文章的提交日期之前提交给期刊的。这些图像包括文章[5–7] 图4A，文章[8] 图4A、5F，文章[9]图 4A、4D 和 5B 中的 Transwell 检测图像，以及文章[10]图 4F 和文章[11]图 5G 中的 Western blot图像，以及文章[12] 图 3E 中流式细胞术图像的复制。Aging 的科学诚信办公室联系了作者，但作者没有回应澄清请求，该论文根据编辑决定被撤回。科学诚信办公室还通知了作者所在的机构此次撤稿，并将他们的名字添加到编辑警告名单中。[1]Jiashi W, Chuang Q, Zhenjun Z, Guangbin W, Bin L, Ming H. MicroRNA-506-3p inhibits osteosarcoma cell proliferation and metastasis by suppressing RAB3D expression.Aging(AlbanyNY).2018;10:1294305. https://doi.org/10.18632/aging.101468 [PubMed]
[2] Ming H, Chuang Q, Jiashi W, Bin L, Guangbin W, Xianglu J. Naringin targets Zeb1 to suppress osteosarcoma cell proliferation and metastasis. Aging (Albany NY). 2018; 10:4141–51. https://doi.org/10.18632/aging.101710 [PubMed][3]Wang J, Wang G, Li B, Qiu C, He M. miR-141-3p is a key negative regulator of the EGFR pathway in osteosarcoma. Onco Targets Ther. 2018; 11:4461–78. https://doi.org/10.2147/OTT.S171304 [PubMed]. Retraction in: Onco Targets Ther. 2023; 16:497–8. https://doi.org/10.2147/OTT.S428160 [PubMed][4]Wang J, He M, Wang G, Fu Q. Organic Gallium Treatment Improves Osteoporotic Fracture Healing Through Affecting the OPG/RANKL Ratio and Expression of Serum Inflammatory Cytokines in Ovariectomized Rats. Biol Trace Elem Res. 2018; 183:270–9. https://doi.org/10.1007/s12011-017-1123-y [PubMed][5]Chen J, Yan C, Yu H, Zhen S, Yuan Q. miR-548d-3p inhibits osteosarcoma by downregulating KRAS. Aging (Albany NY). 2019; 11:5058–69. https://doi.org/10.18632/aging.102097 [PubMed][6]Shan L, Liu W, Zhan Y. Sulfated polysaccharide of Sepiella maindroni ink targets Akt and overcomes resistance to the FGFR inhibitor AZD4547 in bladder cancer. Aging (Albany NY). 2019; 11:7780–95. https://doi.org/10.18632/aging.102286 [PubMed] Retraction in: Aging (Albany NY). 2024; 16:12652–12653. https://doi.org/10.18632/aging.206104 [PubMed][7]Zhao Z, Gao D, Ma T, Zhang L. MicroRNA-141 suppresses growth and metastatic potential of head and neck squamous cell carcinoma. Aging (Albany NY). 2019; 11:921–32. https://doi.org/10.18632/aging.101791 [PubMed]
[8]Wang W, Zhang L, Gao W, Zhang D, Zhao Z, Bao Y. miR-489 promotes apoptosis and inhibits invasiveness of glioma cells by targeting PAK5/RAF1 signaling pathways. Oncol Rep. 2019; 42:2390–401. https://doi.org/10.3892/or.2019.7381 [PubMed]. Retraction in: Oncol Rep. 2023; 49:127. https://doi.org/10.3892/or.2023.8564 [PubMed][9]Wang H, Guo B, Lin S, Chang P, Tao K. Apigenin inhibits growth and migration of fibroblasts by suppressing FAK signaling. Aging (Albany NY). 2019; 11:3668–78. https://doi.org/10.18632/aging.102006 [PubMed][10]Zhou H, Huang Z, Chen X, Chen S. miR-98 inhibits expression of TWIST to prevent progression of non-small cell lung cancers. Biomed Pharmacother. 2017; 89:1453–61. https://doi.org/10.1016/j.biopha.2017.01.012 [PubMed][11]Liu Y, Liu T, Jin H, Yin L, Yu H, Bi J. MiR-411 suppresses the development of bladder cancer by regulating ZnT1. Onco Targets Ther. 2018; 11:8695–704. https://doi.org/10.2147/OTT.S173750 [PubMed][12]Guo B, Su J, Zhang T, Wang K, Li X. Fangchinoline as a kinase inhibitor targets FAK and suppresses FAK-mediated signaling pathway in A549. J Drug Target. 2015; 23:266–74. https://doi.org/10.3109/1061186X.2014.992898 [PubMed]https://www.aging-us.com/article/206128/text
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