杨博士的早期研究成果可通过Google Scholar查询：
https://scholar.google.com/citations?user=0AAAAJ&hl=en。
请将求职信、简历和两位推荐人的联系信息通过电子邮件发送至杨杰博士：
Research Overview
The Jie Yang Lab at the University of Virginia is seeking postdoctoral researchers and visiting scholars. The Yang Lab is dedicated to dissecting the molecular mechanisms of cellular stress response, specifically focusing on mitochondrial stress, endoplasmic reticulum (ER) stress, and downstream integrated stress response (ISR). We employ an interdisciplinary approach, integrating structural biology (Cryo-EM/Cryo-ET), biochemistry (protein characterization), and cell biology (fluorescent imaging). Our ultimate goal is to modulate those stress response pathways in physiological and pathological conditions, potentially leading to the development of novel therapeutics for related human diseases, including neurodegeneration, metabolic disorders, and cancer. In addition, we have established close collaborations with experts in disease-relevant mouse models to complement our mechanistic findings.
Expected Candidates
We welcome applications from individuals interested in investigating the fundamental aspects of any significant biological processes. Ideal candidates should demonstrate self-motivation, a strong research interest, independence, good communication skills, and a collaborative mindset. Candidates with backgrounds and expertise in structural biology, molecular biology, or biochemistry are preferred. Highly motivated individuals with expertise in other fields are also encouraged to apply. Applicants should be well trained in leading projects, experimental design, troubleshooting, and scientific manuscripts writing. This position is fully funded. Competitive salary ($70K/year) and benefits will be provided.
Dr. Jie Yang
Dr. Yang earned his B.S. degree in Life Sciences from Wuhan University. From 2014 to 2019, He pursued his Ph.D. in biophysics at Case Western Reserve University in Cleveland, USA, focusing on studying the molecular mechanisms of inflammasome activation and pyroptotic cell death in innate immunity. From 2019 to 2024, Dr. Yang performed his postdoctoral research at the Scripps Research Institute in San Diego, where he studied the molecular mechanisms of mitochondrial stress response. In 2024, Dr. Yang establishes his independent research laboratory as a tenure-track assistant professor in the Department of Biochemistry and Molecular Genetics at the School of Medicine, University of Virginia.
Recently, Dr. Yang has made exciting preliminary discoveries in the ER stress pathway. The incoming postdoc will have the opportunity to take over those projects, which are likely to yield impactful publications within 1 year or so. Please feel free to reach out for more information and further discussion.
The University of Virginia
Recognized as one of the top universities in the US, the University of Virginia is known as a member of the "Public Ivy" and one of the 25 members of the "New Ivy League." The university consistently ranks among the top 30 best universities in the United States, holding the 24th position in the 2024 U.S. The School of Medicine hosts state-of-art facilities for conducting cutting-edge research, including a 300kV Titian Krios equipped with a K3 direct electron detector, a 200kV Glacios equipped with falcon4 direct electron detector, 200kV F20 and 120kV Spirit screening microscopes, and an Aquilos 2 Cryo-FIB. The Yang Lab has its own vitrobot Mark V (the latest version) installed for freezing cryo-EM grids efficiently.
Living in Charlottesville
Charlottesville, a charming and inclusive town with a rich American history, offers a high quality of life highlighted by affordability, safety, family-friendly neighborhoods, and top-notch schools. Its convenient location near Washington D.C. and Richmond provides easy access to a wealth of tourist attractions, museums, and shopping malls. Outdoor enthusiasts can explore an abundance of hiking and biking trails amidst the breathtakingly beautiful Blue Ridge Mountains.
How to Apply
wfw7nc@virginia.edu.
