【活动预告】染色质与表观遗传学系列讲座第33场 – Kai Ge

学术   2024-09-30 17:18   上海  

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活动时间 | Time



北京时间

2024108日(周二)

晚上20:00-21:00

2024 October 8th Tuesday

20:00-21:00 (Beijing Time)




参与方式 | Location



Zoom网络研讨会: 843 6931 3262

Bilibili直播:

http://live.bilibili.com/22741871

提示:若想通过问答环节等方式与主讲人交流,请下载并安装国际版Zoom客户端,参与Zoom网络研讨会。参与研讨会需输入会议码、姓名、邮箱,无需注册或登陆Zoom账号。


Zoom Webinar ID: 843 6931 3262

Bilibili Live: 

http://live.bilibili.com/22741871

To interact with the speaker, please join the meeting via zoom and make sure you have zoom client (international version) installed.




主讲人 | Speaker



Kai Ge




主讲人简介 | Speaker Biography



戈凯博士是美国国立卫生研究院(NIH)国立糖尿病、消化与肾脏疾病研究所(NIDDK)的高级研究员,并在NIDDK担任系主任。戈凯博士于1992年在复旦大学获得生物化学学士学位;1997年,他在中国科学院上海生物化学研究所获得博士学位,主要研究方向为癌症基因治疗;随后,戈凯博士前往洛克菲勒大学Robert Roeder实验室开展博士后工作,主要研究方向为转录介导因子MED1。2003年,戈凯博士在NIH建立了自己的实验室,并于2011年获得NIH终身教职。戈凯博士实验室细胞命运转变过程中的表观遗传调控,尤其是H3K4甲基转移酶和染色质重塑因子对增强子的调控功能,此外,戈凯博士实验室还密切关注脂肪组织的发育和扩张中的表观遗传调控。

 

Dr. Kai Ge is a Senior Investigator and Acting Branch Chief (Department Chair) at the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health in Washington DC area.  He received BS degree in Biochemistry from Fudan University in 1992 and Ph.D. degree on cancer gene therapy from Shanghai Institute of Biochemistry, Chinese Academy of Sciences in 1997. After postdoctoral training with Robert Roeder at The Rockefeller University working on the Mediator subunit MED1, he set up his own lab at NIH in 2003 and received tenure in 2011.  His lab is interested in epigenomic regulation of cell fate transition, with a focus on enhancer regulation by histone H3K4 methyltransferases and chromatin remodelers.  His lab also investigates epigenomic regulation of adipose tissue development and expansion.




报告标题 | Title



Enhancer regulation by chromatin modifying enzymes in development and cancer




报告摘要 | Abstract



My lab investigates epigenomic regulation of transcription, with a focus on enhancer regulation by chromatin.  I will first review our past 20 years’ work on characterizing the H3K4 mono-methyltransferase KMT2D and understanding its role in enhancer regulation, cell differentiation, animal development, and tumor suppression.  Then I will discuss our recent work on the importance of KMT2D methyltransferase activity and H3K4me1 in enhancer activation, differentiation and development. Next, I will briefly talk about the initial characterization of additional H3K4me1 methyltransferases enriched on enhancers.  Finally, I will talk about enhancer regulation by KMT2D-associated chromatin remodeling or modifying enzymes.  




主讲人近年发表论文摘选 | 

Selected Recent Publications



KMT2 Family of H3K4 Methyltransferases: Enzymatic Activity-dependent and -independent Functions.Van HT, Xie G, Dong P, Liu Z, Ge K. J Mol Biol (2024 Apr 1) 436:168453.

 

ASXLs binding to the PHD2/3 fingers of MLL4 provides a mechanism for the recruitment of BAP1 to active enhancers. Zhang Y, Xie G, Lee JE, Zandian M, Sudarshan D, Estavoyer B, Benz C, Viita T, Asgaritarghi G, Lachance C, Messmer C, Simonetti L, Sinha VK, Lambert JP, Chen YW, Wang SP, Ivarsson Y, Affar EB, Côté J, Ge K, Kutateladze TG. Nat Commun (2024 Jun 7) 15:4883.

 

MLL3/MLL4 methyltransferase activities control early embryonic development and embryonic stem cell differentiation in a lineage-selective manner. Xie G, Lee JE, Senft AD, Park YK, Jang Y, Chakraborty S, Thompson JJ, McKernan K, Liu C, Macfarlan TS, Rocha PP, Peng W, Ge K. Nat Genet (2023 Apr) 55:693-705.

 

MED1 is a lipogenesis coactivator required for postnatal adipose expansion.

Jang Y, Park YK, Lee JE, Wan D, Tran N, Gavrilova O, Ge K. Genes Dev (2021 May 1) 35:713-728.

 

Interplay of BAF and MLL4 promotes cell type-specific enhancer activation. Park YK, Lee JE, Yan Z, McKernan K, O'Haren T, Wang W, Peng W, Ge K. Nat Commun (2021 Mar 12) 12:1630.


本活动由Active Motif赞助

Sponsored by: Active Motif

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