2024 ASH | “医”往无前!中国专家70余篇佳作闪耀圣迭戈

健康   2024-11-08 15:01   北京  






一年一度的美国血液学会(ASH)年会作为全球血液学领域最负盛名的国际学术盛会之一,历年来备受瞩目,每年均吸引着全球范围内众多顶尖专家学者共襄盛举。2024年,第66届ASH年会定于12月7日-10日在美国圣迭戈召开。此次年会不仅将作为全球血液学研究的璀璨舞台,公布一系列顶尖的研究摘要,引领学术前沿,更将深度聚焦如何优化患者管理与治疗策略,以及探索创新的治疗途径,为血液学领域的发展注入新的活力。本届ASH年会提交的摘要数量再创历史新高,多达7950余篇佳作被接纳,充分彰显了全球血液学研究领域的蓬勃生机与无限潜力。


尤为值得一提的是,近年来,中国在临床研究领域的迅猛崛起,不仅推动了国内血液学研究的快速发展,更显著提升了中国在全球血液学领域的影响力与话语权。根据ASH官网于当地时间11月5日上午9:00公布的最新摘要信息,医脉通小编检索到今年共有75篇中国专家汇报的研究入选Oral Abstracts,再创新高。这一数字不仅彰显了我国血液学研究的卓越成就,更预示着中国学者在国际舞台上的影响力正持续增强。


医脉通特将此次入选的75篇研究相关信息进行了整理,旨在为广大读者呈现一场精彩纷呈的学术盛宴,让我们共同见证中国血液学研究在全球舞台上的辉煌时刻。







摘要号:12

标题:Rbm38 Regulates Heme Biosynthesis Via Fine-Tuning the RNA Alternative Splicing, Stability and Translation of Porphyrin Metabolic Enzyme Gene Ferrochelatase (Fech)


报告人及单位:Yang Mei,湘潭市中心医院




摘要号:30

标题:Clec16a-Mediated Mitophagy Modulates Zebrafish Definitive Hematopoiesis


报告人及单位:Shuyang Cai,上海中医药大学附属市中医医院




摘要号:38

标题:The TFG-ROS1 Fusion Is an Oncogenic Driver of Human Myeloid Leukemia


报告人及单位:Jie Sun,浙江大学医学院附属第一医院




摘要号:54

标题:Targeting PRMT9 Overcomes Venetoclax Resistance in AML By Modulating Splicing and Inhibiting Translation


报告人及单位:Yang Li,福建医科大学附属协和医院




摘要号:89

标题:Targeted-Delivery Strategy of Engineered EV Functionalized By Anti-CD3/CD19 Bi-Specific T-Cell Engager in Treating B-Cell Malignancies


报告人及单位:杨秀秀,中国医学科学院血液病医院(中国医学科学院血液学研究所)




摘要号:91

标题:Rituximab, Lenalidomide, and Zanubrutinib (ZR2) with Sequential CAR-T Cell As First-Line Therapy for High-Risk Large B Cell Lymphoma


报告人及单位:Mingming Zhang,浙江大学医学院附属第一医院




摘要号:92

标题:IL-10 Expressing CD19 CAR-T Cells Induce Complete Remission and Improve Long-Term Protection in Relapsed or Refractory B-Cell Hematological Malignancies


报告人及单位:Jingjing Ren,深圳莱芒生物科技有限公司




摘要号:97

标题:JAK/Rock Inhibitor Rovadicitinib for Glucocorticoid-Refractory or -Dependent Chronic Graft-Versus-Host Disease:Updated Results of Multicenter, Phase 1b/2a Trial


报告人及单位:赵妍敏,浙江大学医学院附属第一医院




摘要号:99

标题:A Phase II Study to Evaluate the Efficacy and Safety of Pimicotinib (ABSK021) in Chronic Graft Versus Host Disease (cGvHD) after 1 or More Lines of Systemic Treatment


报告人及单位:吴德沛,苏州大学附属第一医院




摘要号:101

标题:Multiomic Analyses Uncover Immune Signatures of Steroid-Refractory Graft-Versus-Host Disease


报告人及单位:Zengkai Pan,上海交通大学医学院附属瑞金医院




摘要号:125

标题:Imbalanced Expression of TACI Isoforms Regulated By TNFRSF13B Variants Promotes the Progression of Epstein-Barr Virus-Associated Lymphoproliferative Diseases


报告人及单位:Xinyue Deng,华中科技大学同济医学院附属同济医院




摘要号:150

标题:Efficient Generation of CAR-T By the First Coacervate-Based Gene Delivery System


报告人及单位:Peipei Zhu,西湖大学




摘要号:156

标题:Potent in Vitro and In Vivo Efficacy of Hdz-C123A, a GSPT1 Degrader-Antibody Conjugate Targeting CD123 in Acute Myeloid Leukemia


报告人及单位:Yu Guo,浙江大学(杭州)创新医药研究院




摘要号:164

标题:Reconstruction of Megaloblastic Anemia in a Novel Erythroblastic Island Humanized Mouse Model with Mature Circulating Human Red Blood Cells


报告人及单位:Shuang Liu,南京大学化学和生物医药创新研究院




摘要号:192

标题:Exploring the Mechanism of Chromatin Spatial Structure Changes and Transcriptional Regulation in Age-Related Clonal Hematopoiesis Caused By DNMT3A Mutations Using Chromatin Capture Technology


报告人及单位:Yujun Dai,中山大学肿瘤防治中心




摘要号:222

标题:Prospective Study of Avapritinib in Patients with Relapsed/Refractory or MRD-Positive Core-Binding Factor Acute Myeloid Leukemia with KIT Mutations


报告人及单位:Xueqing Dou,苏州大学附属第一医院




摘要号:263

标题:Targeting the Hypoxic Microenvironment in Cutaneous Chronic Graft-Versus-Host Disease through PI3Kδ Inhibition


报告人及单位:Yuxi Xu,陆军军医大学第二附属医院(新桥医院)




摘要号:266

标题:Elevated Dosing of Recombinant Human Thrombopoietin Accelerates Platelet Engraftment in Allogeneic Hematopoietic Stem Cell Transplantation: A Prospective, Dosage-Optimization, Controlled Clinical Study


报告人及单位:Dan Feng,中国医学科学院血液病医院(中国医学科学院血液学研究所)




摘要号:268

标题:Epstein-Barr Virus Reactivation and Post-Transplant Lymphoproliferative Disorders after Allo-HSCT in the Era of Letermovir for Cytomegalovirus Prophylaxis


报告人及单位:Jingtao Huang,上海血液学研究所




摘要号:270

标题:Safety and Efficacy of VA Combined with Modified BuCy Conditioning Regimen Followed By Allo-HSCT for High-Risk or Refractory/Relapsed Acute Lymphoblastic Leukemia : A Prospective, Single-Center, Single-Arm Clinical Trial


报告人及单位:Xiaoqian Chen,苏州大学附属第一医院




摘要号:300

标题:Effects of Low-Molecular-Weight Heparin on Pregnancy Outcomes in Protein S Deficiency: A Prospective, Randomized Controlled Phase II Clinical


报告人及单位:臧梦桐,北京大学人民医院




摘要号:304

标题:Hetrombopag Added to Immunosuppressive Therapy in First-Line Treatment of Severe Aplastic Anemia: A Randomized, Double-Blind, Placebo-Controlled Phase 3 Trial


报告人及单位:张凤奎,中国医学科学院血液病医院(中国医学科学院血液学研究所)




摘要号:312

标题:Efficacy and Safety of Adding Blinatumomab to First-Line Treatment for Chinese Children with B-Cell Acute Lymphoblastic Leukemia


报告人及单位:Ruidong Zhang,首都医科大学附属北京儿童医院




摘要号:328

标题:Integrative Multi-Omics Analyses Identify a High-Risk Subgroup of Patients with Poor Prognosis in t(8;21) Acute Myeloid Leukemia


报告人及单位:Yu Liu,中国医学科学院血液病医院(中国医学科学院血液学研究所)




摘要号:345

标题:Mitochondrial Transcriptional-Translational Conflict Contributes to Defective Erythropoiesis and Disease Progression in Splicing Factor Mutant Myelodysplastic Syndromes


报告人及单位:李巧利,中国医学科学院血液病医院(中国医学科学院血液学研究所)




摘要号:372

标题:Modified Dual CLL1-CD15 and CLL1-CD16 Icar-T Cells for Mitigating Granulocytopenia Toxicities in the Treatment of Acute Myeloid Leukemia


报告人及单位:Rui Zhang,天津市第一中心医院




摘要号:378

标题:A Multi-Center Clinical Trial of Allogeneic Hematopoietic Stem Cell Transplants in Transfusion Dependent Thalassemia


报告人及单位:刘容容,广西医科大学第一附属医院




摘要号:420

标题A Single-Cell Transcriptomic Atlas of Cytokine Storm in CAR-T Therapy, COVID-19, and SLE


报告人及单位Xia Li,浙江大学医学院附属第一医院




摘要号:425

标题:β2-Adrenergic Receptor Agonist Terbutaline Regulates Macrophage Polarization Via HMGB1 in Immune Thrombocytopenia


报告人及单位:郭秋雨,北京大学人民医院




摘要号:426

标题:Differentiation Route Generates Functional Biased Platelets and Responses Distinctly to Varying Physiological Demands


报告人及单位:Jingkun Liu,中国科学院北京基因组研究所(国家生物信息中心)




摘要号:437

标题:ERAD Activity Distinguishes the Functional Heterogeneity of Hematopoietic Stem Cells


报告人及单位:QinLu Peng,湖南大学




摘要号:438

标题:SNORD113-114 Cluster Maintains Hematopoietic Stem Cell Self-Renewal Via Orchestrating the Translation Machinery


报告人及单位:Hui Wang,浙江大学医学院附属第一医院




摘要号:452

标题:Spatial Architecture of Immune Microenvironment Orchestrating Anti-Lymphoma Immunity and the Response to Immunochemotherapy in EBV+ Diffused Large B Cell Lymphoma Revealed By Imaging Mass Cytometry and Spatial Transcriptome


报告人及单位:林志娟,厦门大学附属第一医院




摘要号:477

标题:Safety and Efficacy of Tgrx-678, a Potent BCR::ABL1 allosteric Inhibitor, in Patients with Tyrosine Kinase Inhibitor Resistant and/or Intolerant Chronic Myeloid Leukemia: Updated Results of Phase 1 Study Tgrx-678 -1001


报告人及单位:江倩,北京大学人民医院




摘要号:480

标题:Olverembatinib As Second-Line (2L) Therapy in Patients (pts) with Chronic Phase-Chronic Myeloid Leukemia (CP-CML)


报告人及单位:黎纬明,华中科技大学同济医学院附属协和医院




摘要号:484

标题:Rovadicitinib in Patients with Myelofibrosis Who Were Refractory or Relapsed or Intolerant to Ruxolitinib: A Single Arm, Multicenter, Open-Label, Phase Ib Study


报告人及单位:常春康,上海市第六人民医院




摘要号:486

标题:First-in-Human Phase I/IIa Safety and Efficacy of Flonoltinib Maleate, a New Generation of JAK2/FLT3 Inhibitor in Myelofibrosis


报告人及单位:Lijuan Chen,四川大学华西医院




摘要号:538

标题:Polycomb Repressive Complex 2 Regulates Differentiation-Stage-Specific Autophagy Gene Expression and Safeguards Normal Erythropoiesis


报告人及单位:Jiazhuo Li,广州市第一人民医院(华南理工大学附属第二医院)




摘要号:539

标题:A Novel Role of LKB1 in Erythroblast Enucleation


报告人及单位:Yuanlin Xu,河南省肿瘤医院




摘要号:562

标题:Procr+ Endothelial Progenitor Cells Modulate Adult Hematopoiesis and Microenvironment Homeostasis Via Notch Signaling


报告人及单位:Chang Xu,中国医学科学院血液病医院(中国医学科学院血液学研究所)




摘要号:576

标题:Clinical Implications of CSF-Ctdna Positivity in Newly Diagnosed Diffuse Large B Cell Lymphoma in a Large Cohort


报告人及单位:梁金花,江苏省人民医院




摘要号:599

标题:Myeloablative Allogeneic Hematopoietic Stem Cell Transplantation Improved Prognosis for Advanced NK/T Cell Lymphoma


报告人及单位:李智慧,北京高博博仁医院




摘要号:663

标题:Decitabine Plus All-Trans Retinoic Acid Versus Decitabine Monotherapy for Myelodysplastic Syndromes with Excess Blasts: A Multicentre, Randomized Controlled Trial


报告人及单位:佟红艳,浙江大学医学院附属第一医院




摘要号:681

标题:Safety and Efficacy of Bicistronic CD19/CD22 CAR T Cell Therapy in Childhood B Cell Acute Lymphoblastic Leukemia


报告人及单位:Hua Zhang,上药生物治疗(香港)有限公司




摘要号:682

标题:CD19 CAR T-Cell Therapy in Refractory Autoimmune Hemolytic Anemia


报告人及单位:李若难,中国医学科学院血液病医院(中国医学科学院血液学研究所)




摘要号:683

标题:Sequential Infusion of Anti-CD19 and Anti-BCMA Chimeric Antigen Receptor T-Cells: A Promising Treatment Strategy for Refractory Immune-Mediated Platelet Transfusion Refractoriness


报告人及单位:Yunju Ma,苏州大学附属第一医院




摘要号:690

标题:Parvovirus B19 Originates from Infected Hematopoietic Stem Cells Following Hematopoietic Stem Cell Transplantation


报告人及单位:裴旭颖,北京大学人民医院




摘要号:696

标题:Haploidentical Peripheral Blood Stem Cell Combined with Bone Marrow or Unrelated Cord Blood As Grafts for Acute Leukemia/Myelodysplastic Syndrome: An Open-Label, Multicenter, Randomized, Phase 3 Trial


报告人及单位:Sijian Yu,南方医科大学南方医院





摘要号:711

标题:Preliminary Efficacy and Safety Results of TQB3473, a Novel Syk Inhibitor, in Adult Patients with Immune Thrombocytopenia (ITP)


报告人及单位:周虎,河南省肿瘤医院




摘要号:712

标题:Updated Outcome from Biomarker MSC-C5b-9-Guided All-Trans Retinoic Acid Treatment for Resistant/Recurrent ITP: A Multicenter, Randomized, Open-Label, Phase 3 Clinical Trial


报告人及单位:李梦琳,北京大学人民医院




摘要号:806

标题:Rovadicitinib in Patients with Hemophagocytic Lymphohistiocytosis: A Single Arm, Open-Label, Phase I Study


报告人及单位:王昭,首都医科大学附属北京友谊医院




摘要号:810

标题:Pharmacological and Mechanism Study of a New RIPK1 Inhibitor Via Necroptosis to Treat Hemophagocytic Lymphohistiocytosis


报告人及单位:Jinbing Zhu,四川大学华西医院




摘要号:832

标题:TENT5C As a Target of Chromatin Remodeler SMARCA2 Participates BTK Inhibitor Resistance in Mantle Cell Lymphoma By Regulating ATP Metabolism


报告人及单位:阎禹廷,中国医学科学院血液病医院(中国医学科学院血液学研究所)




摘要号:833

标题:ST6GALNAC4 Promotes Diffuse Large B-Cell Lymphoma Progression Via Mediating Sialylation of Bmpr-1B at Thr24


报告人及单位:Yu Zhang,山东省立医院




摘要号:836

标题:Venetoclax Combined with Hag Regimen in Newly Diagnosed ETP-ALL: A Prospective, Multicenter, Phase 2 Trial


报告人及单位:Shanshan Suo,浙江大学医学院附属第一医院




摘要号:839

标题:Tucidinostat Plus Pediatric-Inspired Chemotherapy As First-Line Therapy for Newly Diagnosed ETP-ALL/Lbl: An Open-Label, Single-Arm, Phase 2 Trial


报告人及单位:Jieping Lin,南方医科大学南方医院




摘要号:843

标题:The Mutated of KRAS gene Determine the Fate of KMT2A-Rearranged AML Patients


报告人及单位:吴一波,浙江大学医学院附属第一医院




摘要号:874

标题:CD38 Overexpressed Monocytes Play a Critical Role in the Fibrogenesis in Myeloproliferative Neoplasms and Can be Used As a Therapeutic Target to Ameliorate Fibrosis


报告人及单位:李冰,中国医学科学院血液病医院(中国医学科学院血液学研究所)




摘要号:893

标题:Venetoclax Plus Dexamethasone As First-Line Treatment for t(11; 14) Light-Chain Amyloidosis: Preliminary Result of a Phase II Prospective, Multicenter, Single-Arm Study


报告人及单位:Kaini Shen,北京协和医院




摘要号:904

标题:CD33 Antibody-Modified Nanoparticles Encapsulated IL-15 Induce ISG15 to Promote MHC I Expression in Leukemia Cells Via Innate Immunity Pathway Inducing Graft-Versus-Leukemia without Aggravating Graft-Versus-Host Disease


报告人及单位:Ruowen Wei,华中科技大学同济医学院附属协和医院




摘要号:921

标题:A Novel Generation of Anti-CD7 Universal CAR-T Therapy for Patients with Relapsed or Refractory CD7 Positive T-ALL/Lbl: A Phase I Clinical Trial


报告人及单位:胡永仙,浙江大学医学院附属第一医院




摘要号:923

标题:A Prospective Investigator-Initiated Phase 1/2 Study of BCMA/CD19 Dual-Targeting CAR T Therapy in Patients with Relapsed/Refractory Multiple Myeloma Including Those with Extramedullary Disease


报告人及单位:姜华,上海第四人民医院




摘要号:956

标题:A Highly Selective and Orally Bioavailable CK1α Molecular Glue Degrader Targets B-Cell Lymphoma Cells


报告人及单位:Ran Kong,山东省立医院




摘要号:958

标题:KPT-330 Combined with Radiation Therapy: Effective Central Nervous System Lymphoma Treatment with Reduced Neurotoxicity


报告人及单位:李炳宗,苏州大学附属第二医院




摘要号:960

标题:CD93+ Myeloid Cells Suppress T-Cell-Mediated Anti-Tumor Immunity


报告人及单位:于慧,北京大学肿瘤医院




摘要号:964

标题:CD7 CAR T-Cell Therapy in Relapsed or Refractory T-Cell Acute Lymphoblastic Leukemia: A Retrospective Study


报告人及单位:潘静 ,北京高博博仁医院




摘要号:971

标题:Venetoclax and Decitabine Compared with Standard Intensive Chemotherapy As Induction Therapy in Newly Diagnosed Acute Myeloid Leukemia: Updated Results of a Multicenter, Randomized, Phase 2b Trial


报告人及单位:Jing Lu,苏州大学附属第一医院




摘要号:972

标题:High-Dose Cytarabine with Idarubicin Versus High-Dose Cytarabine within First Consolidation for Acute Myeloid Leukemia in First Complete Remission: An Open-Label, Multicenter, Randomized, Phase 3 Trial


报告人及单位:Zinan Feng,南方医科大学南方医院




摘要号:977

标题:Faecalibacterium Prausnitzii Confers a Protective Effect Against the Development of NKTCL


报告人及单位:Zhuangzhuang Shi,郑州大学第一附属医院




摘要号:986

标题:Final Analysis of a Phase 1 Study of Zanubrutinib Plus Lenalidomide in Patients With Relapsed/Refractory Diffuse Large B-cell Lymphoma


报告人及单位:宋拯,天津医科大学肿瘤医院




摘要号:1002

标题:The Efficacy and Safety of Selinexor in Combination with Ruxolitinib in Ruxolitinib-Treated Myelofibrosis Patients: The Interim Analysis of a Prospective, Open-Label, Multicenter, Parallel-Cohort, Phase 2 Study


报告人及单位:段明辉,北京协和医院




摘要号:1028

标题:A Single-Center, Single-Arm, Phase I Clinical Trial of Anti-BCMA/GPRC5D Bispecific CAR T-Cells in Patients with Refractory and Relapsed Multiple Myeloma with Extramedullary Disease


报告人及单位:邱玲,中国人民解放军西部战区总医院




摘要号:1044

标题:A Multicenter Randomized Controlled Trial of Low-Dose Ruxolitinib for Gvhd Prophylaxis in Haploidentical Hematopoietic Stem Cell Transplantation


报告人及单位:Hengwei Wu,浙江大学医学院附属第一医院




摘要号:1049

标题:Mini-Dosed Blinatumomab Maintenance Therapy Following Allogeneic Hematopoietic Stem Cell Transplantation in Acute B-Cell Lymphoblastic Leukemia


报告人及单位:季杰,四川大学华西医院




摘要号:1050

标题:Updated Results from a Phase Ⅱ Clinical Trial:Safety and Efficacy of Azacitidine and Chidamide Maintenance after Allogeneic Hematopoietic Stem Cell Transplantation for Patients with High-Risk Acute Myeloid Leukemia


报告人及单位:黄睿,南方医科大学珠江医院




排名不分先后,按照摘要号进行排序,

本文纳入了报告人单位所属地为中国的研究,

如有遗漏或任何问题,请给我们留言~






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