可逆性胼胝体压部综合征
表1 RESLES相关疾病谱
图1 RESLES发病机制
感染、炎症、外伤等导致炎症细胞及炎症因子激活，星形胶质细胞产生大量谷氨酸(上图)。谷氨酸为兴奋性神经递质，激活胶质细胞表面NMDA受体、AMPA受体、钠钾泵及水通道蛋白，导致水进入星形胶质细胞及神经元，从而导致细胞毒性水肿
图2 COVID-19患者中的RESLES
胼胝体压部的椭圆形病变，呈T2/FLAIR高信号(A.a、A.b)，DWI高信号(B.a、B.c)，在多色ADC上为异常弥散受限(B.b、B.d)，T1低信号且不伴强化(C)。
参考文献
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[3] Moreau A, Ego A, Vandergheynst F, et al. Cytotoxic lesions of the corpus callosum (CLOCCs) associated with SARS-CoV-2 infection. J Neurol. 2021;268(5):1592-1594.
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本期作者：严婧文
本期编辑：范思远 姜南
本期审阅：关鸿志
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北京协和医院神经科 · 1921
