主题演讲：CNS, Immunology，以及AI | 2024 BioSpark年会

Gordon Freeman, PhD, Professor of Medicine at Dana-Farber Cancer Institute and Harvard Medical School, is renowned for discovering the PD-L1 and PD-L2 proteins. Dr. Freeman showed that PD-L1 and PD-L2 bound to PD-1 to turn off the immune response and that blockade of PD-L1/PD-1 enhanced immune responses.  He further showed that PD-L1 is highly expressed on many tumors and allows these tumors to resist immune attack. Dr. Freeman’s work led directly to the development of a successful strategy for cancer immunotherapy - blocking the PD-1-ligand interaction. Dr. Freeman has published over 400 scientific papers and holds over 90 US patents on immunotherapies. He was elected to the National Academy of Sciences and the National Academy of Inventors, is a Fellow of the AACR and SITC Academies, and has received numerous awards, including the William B. Coley Award for Distinguished Research in Tumor Immunology, the Warren Alpert Foundation Prize, and the Richard Smalley, MD, Memorial Award. Dr. Freeman received his Ph.D. degree in Microbiology and Molecular Genetics from Harvard University.

Dr. Feng is the Poitras Professor of Neuroscience in the Department of Brain and Cognitive Sciences, an Investigator and Associate Director of the McGovern Institute for Brain Research, Director of the Hock E. Tan and K. Lisa Yang Center for Autism Research of the Yang Tan Collective at Massachusetts Institute of Technology. He is also an Institute Member and the Director of Model Systems and Neurobiology at the Stanley Center for Psychiatric Research at Broad Institute of MIT and Harvard. Dr. Feng’s research is devoted to understanding the mechanisms regulating the development and function of synapses in the brain and how synaptic and circuit dysfunction may contribute to brain disorders. Using genetically engineered animal models, Dr. Feng’s laboratory combines cutting-edge technologies and multidisciplinary approaches to unravel the neurobiological mechanisms of neurodevelopmental and psychiatric disorders. Dr. Feng’s lab is also a leading lab in developing genetic tools and animal models for neuroscience and brain disorder research.

Dr. Feng has won numerous awards for his scientific achievements including Beckman Young Investigator Award, Gill Young Investigator Award, McKnight Neuroscience of Brain Disorders Award, McKnight Technology Innovation Award, and Hartwell Individual Biomedical Research Award. Dr. Feng is a member of the National Academy of Sciences, National Academy of Medicine and American Academy of Arts and Sciences, and a fellow of American Association for the Advancement of Science.

Dr. Feng studied medicine at Zhejiang University School of Medicine in the beautiful city of Hangzhou, China.  He obtained his PhD from the State University of New York at Buffalo in the laboratory of Dr. Linda Hall and postdoctoral training at Washington University in St. Louis under the guidance of Dr. Joshua Sanes. Prior to joining the faculty at MIT, he was a faculty member in the Department of Neurobiology, Duke University School of Medicine.

Manolis Kellis is a Professor of Computer Science at MIT, a member of the Broad Institute of MIT and Harvard, and a member of the Computer Science and Artificial Intelligence Lab at MIT where he directs the MIT Computational Biology Group (compbio.mit.edu). His research is in disease genetics, epigenomics, gene circuitry, non-coding RNAs, comparative genomics, and phylogenetics. He has authored more than 230 journal publications that have been cited more than 115,000 times. He has helped direct several large-scale genomics projects, including the Roadmap Epigenomics project, the comparative analysis of 29 mammals, the human and the Drosophila Encyclopedia of DNA Elements (ENCODE) project, and the Genotype Tissue-Expression (GTEx) project. He received the US Presidential Early Career Award in Science and Engineering (PECASE), the NSF CAREER award, the Alfred P. Sloan Fellowship. He obtained his Ph.D. from MIT, where he received the Sprowls award for the best doctorate thesis in computer science. He lived in Greece and France before moving to the US. 

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