Oncotarget
2024 Dec 2;22(1):746.
doi: 10.1186/s12951-024-03026-x.
A green, versatile, and facile strategy for anti-biofouling surface with ultra-high graft density polyethylene glycol
Wenjie Liu 1 2, Suqin He 3, Hao Liu 1, Zeyu Shou 2 4, Kaiyuan Huo 2, Hongping Xiang 5, Aihan Feng 5, Wei Lu 6, Na Li 7
Affiliations expand
PMID: 39617916
PMCID: PMC11610065
DOI: 10.1186/s12951-024-03026-x
Abstract
Implantable catheters are susceptible to severe complications due to non-specific protein adhesion on their surfaces. Polyethylene glycol (PEG) coatings, the gold standard for resistance to non-specific protein adhesion, present a challenge in achieving high-density grafting, which significantly restricts their use as anti-biofouling coatings. Herein, we exploited the strong interaction between polyphenols (PCs) and polycations (K6-PEG) to graft PEG onto the surface of PC-Cu (A network of metal polyphenols composed of proanthocyanidins and metal copper ions, with expectation for the coating with excellent resistance to non-specific protein adhesion (PC-Cu@K6-PEG). The introduction of K6-PEG resulted in enhanced stability and modulus of PC-Cu, as well as a reduction in the surface adhesion energy and contact angle of PC-Cu. In contrast to previously reported PEG coatings, PC-Cu@K6-PEG exhibited a markedly elevated grafting density of PEG (4.06 chains/nm²), which was more than double the highest value previously reported (1.9 chains/nm²), due to the diffusing ability of K6-PEG throughout the PC-Cu networks. PC-Cu@K6-PEG displays robust resistance to a variety of proteins, microbials, and platelet attachment, thereby preventing thrombosis. The coating ability of PC-Cu onto diverse substrates, combined with the simple, straightforward and environmentally benign process of fabricating PC-Cu@K6-PEG, suggests that this strategy has significant potential for use in anti-biofouling surfaces.
Keywords: Anti-biofouling coating; Metal-phenol networks (MPNs); Non-specific adsorption; Peptide; Polyethylene glycol (PEG).
参考链接：https://pubpeer.com/publications/261C47569C64A7C5B566A01C5AD4A8
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