01
Erickson HL, et al.
Immunity. 2024.
DOI: 10.1016/j.immuni.2024.07.004
02
Liu B, et al.
Burns Trauma. 2024.Sepsis-induced acute lung injury (ALI) leads to severe hypoxaemia and respiratory failure, resulting in a poor prognosis for septic patients. Endotoxin dissemination triggers oxidative stress and inflammatory cytokine release in macrophages, initiating diffuse alveolar injury. The role of epigenetic modifications of histones in organ damage is increasingly recognised. The aim of this study was to investigate the use of histone modification inhibitors to attenuate sepsis-induced ALI and to reveal new strategies to improve the survival of sepsis patients. This study reveals for the first time that BRD3308 ameliorates sepsis-induced ALI by promoting H3K27 acetylation through inhibition of the enzymatic activity of histone deacetylase (HDAC) 3. The study highlights the role of HDAC3 in exacerbating inflammatory responses and tissue damage by mediating histone deacetylation. Histone deacetylation has a partial role in regulating oxidative stress in macrophages.H3K27 acetylation in macrophages during ALI enhances autophagy to play a protective role by regulating the expression of the key autophagy protein ATG5.
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