All about stress:
Why do we feel it, how does it affect us, and how do we resist
Introduction
Nakamura K et al. (2022) Nature reviews. Neuroscience. 23(1):35-52.
Regarding the introduction part of our JC discussion, we will explore recent insights into the neural mechanisms by which stress-responsive brain circuits regulate both physiological and immune responses to environmental and psychological stressors. One study highlights a hypothalamomedullary pathway linking the hypothalamus and brainstem, orchestrating responses to environmental stressors like cold and infection by modulating autonomic and motor systems to sustain homeostasis. Another study reveals that chronic psychological stress activates central pathways to immune organs, such as the bone marrow and spleen, through regions like the hypothalamus and amygdala, driving immune responses that may lead to inflammation and stress-related disorders. These studies collectively reveal the bidirectional link between brain circuits and peripheral immunity, emphasizing how central stress mechanisms shape both health and disease.
Main paper I
Resilience, a mental elasticity in individuals when rebounding from adversity, is a common process. Understanding of the mechanism behind it might shed a light on cure of depression. A recent study has indicated that activation of parvalbumin (PV) interneurons in the primary auditory cortex (A1) by thalamic inputs from the ipsilateral medial geniculate body (MG) is essential for resilience in mice exposed to chronic social defeat stress. In addition, temporal neural plasticity of MGA1 neurons could initiated synaptogenesis onto thalamic PV neurons via presynaptic BDNF-TrkB signaling in subsequent stress responses. Moreover, further optogenetic mimicking verified the significance of the short-term hyperpolarization of MGA1 neurons in the resilience mechanisms, indicating a new strategy for targeted neuromodulation.
Li HY et al. (2023) Cell. 86(7):1352-1368.e18.
Main paper II
Major depressive disorder (MDD) is a leading cause of disease burden worldwide. While the incidence, symptoms and treatment of MDD all point toward major sex differences, the molecular mechanisms underlying this sexual dimorphism remain largely unknown. By combining differential expression and gene coexpression network analyses, authors provide a comprehensive characterization of male and female transcriptional profiles associated with MDD across six brain regions. Their results show a major rearrangement of transcriptional patterns and key regulators in MDD, with limited overlap between males and females, an effect seen in both depressed humans and stressed mice.
Labonté B et al. (2017) Nature Medicine. 23(9):1102-1111.
“
JC 基本信息
/ INFORMATIONS
时间
2024年11月17日14：00-17：00
地点
北京大学吕志和楼B106
主讲人
王艺儒 李浩田 王瑞扬
嘉宾
甘怡群（北京大学心理与认知科学学院）
李坤 （清华大学生命科学联合中心）
班主任
Jackson Champer
欢迎感兴趣的同学给主讲人发邮件报名旁听本次JC：
王艺儒 2100012172@stu.pku.edu.cn
李浩田 haotian_li@stu.pku.edu.cn
王瑞扬 ryk010@stu.pku.edu.cn
本次JC提供晚餐，如有忌口请在邮件中一并告知。
Reference
【Introduction】Nakamura K et al. (2022) Nature reviews. Neuroscience. 23(1):35-52.
【Main paper I】Li HY et al. (2023) Cell. 86(7):1352-1368.e18.
【Main paper II】Labonté B et al. (2017) Nature Medicine. 23(9):1102-1111.
供稿｜王艺儒 李浩田 王瑞扬
排版｜张静函
审核｜赵文迪
