Lab introduction
The University of Texas Southwestern Medical Center (UTSW) is an elite research institution, with ongoing support from the National Institutes of Health and other federal agencies, foundations, individuals, and corporations providing more than $360 million per year to fund research. The faculty includes many distinguished members who have inspired the development of the Medical Center over this time, including 6 Nobel laureates, 22 National Academy of Science members, 16 National Academy of Medicine members and 13 investigators in the Howard Hughes Medical Institute.
The Tao Wang Lab is a top and well-established bioinformatics research group at UTSW. Statistics, informatics, medicine, and biology are the four integral pillars of Tao Wang Lab’s interdisciplinary research program. Dr. Wang’s group has been working on mining public and in-house high throughput data to achieve a deeper understanding of the immunology of various human diseases, with a heavy emphasis on cancers, and its implications for diagnosis, prognosis, and treatment. The core research interest of Wang Lab is in development of methodologies for analyses of immunogenomics, computational immunology, scRNA-seq data, and spatial transcriptomics data. The ultimate goal is to impact the prognosis and treatment of patients suffering from cancers and other diseases, through modeling of high dimensional data, especially immunogenomics data. Tao Wang Lab has published 89 papers in top journals, such as Nature Methods (2024, Zhu, Chang, and Wang et al), Genome Biology (2023, Yang et al), Nature Machine Intelligence (2022, Zhang and Park et al), Nature Machine Intelligence (2021, Lu et al), Nature Methods (2021, Zhang et al), Science Immunology (2020, Lu et al), Cancer Discovery (2018, Wang et al), SMMR (2020, Park et al), Cell (2019, Zhu et al), since its establishment in 2016. Wang Lab holds two patents.
At UTSW, there are great opportunities for scientists to collaborate with outstanding biomedical investigators and work on exciting research projects. UT Southwestern and the Tao Wang Lab provide a friendly, dynamic, collaborative, and integrative research and training environment with state-of-the-art facilities. UTSW is an Affirmative Action/Equal Opportunity Employer. Women, minorities, veterans and individuals with disabilities are encouraged to apply.
Position Title
Postdoctoral Fellow (Bioinformatics/Computational Biology/Computer Science/Machine or Deep Learning/Biostatistics). We welcome post-doctoral fellows with interest in 100% “dry” research or research that is half “dry” and half “wet”. We welcome post-doctoral fellows who switch from 100% “wet” research background, as long as he/she has demonstrated a keen interest in, has a decent exposure to, and has a clear potential for “dry” research.
Duties & Responsibilities
The projects include (1) developing novel methods for analysis and integration of genomics, proteomics, spatial/imaging and other forms of high-dimensional -omics data, and developing prediction models for patients’ clinical outcomes, (2) assembling and statistical analyses of big biomedical data to reveal significant and novel biological insights, (3) creating databases and websites for management of big biological data. (4) Application for independent funding under the support of the PI.
Position Qualifications
Candidates should have a doctoral degree (or will have one soon) in either one of the following fields, including genetics/genomics, bioinformatics, computational biology, computer science, biostatistics, or a related field.
Lab website
Lab website
https://qbrc.swmed.edu/labs/wanglab/index.php
Google scholar:
https://scholar.google.com/citations?user=nu0-Gn4AAAAJ&hl=en
QBRC with which Wang lab is affiliated with
https://qbrc.swmed.edu/
School of Public Health with which Wang lab is affiliated with
https://www.utsouthwestern.edu/education/public-health/
Recent publications
(1)Mapping cellular interactions from spatially resolved transcriptomics data. Nature Methods. 2024
(2)Cytomulate: accurate and efficient simulation of CyTOF data. Genome Biology. 2023
(3)Sprod for De-noising Spatial Transcriptomics Data Based on Position and Image Information. Nature Methods. 2022.
(4)Benisse for Interpreting the B Cell Receptor Repertoire with Single Cell Gene Expression. Nature Machine Intelligence. 2022.
(5)Deep learning-based prediction of the T cell receptor-antigen binding specificity. Nature Machine Intelligence. 2021.
(6)Mapping the Functional Landscape of T Cell Receptor Repertoire by Single T Cell Transcriptomics. Nature Methods. 2020.
(7)Tumor Neoantigenicity Assessment with CSiN Score Incorporates Clonality and Immunogenicity to Predict Immunotherapy Outcomes. Science Immunology. 2020.
(8)Somatic Mutations Increase Hepatic Clonal Fitness and Regeneration in Chronic Liver Disease. Cell. 2019.
Contact
Please send your CV to: Dr. Tao Wang (Tao.Wang@UTSouthwestern.edu). Please don’t add compressed files (e.g. zip files) in the email attachment, which will be blocked by UTSW firewall.
Application Deadline
Until filled
UT Southwestern Medical Center is committed to an educational and working environment that provides equal opportunity to all members of the University community. As an equal opportunity employer, UT Southwestern prohibits unlawful discrimination, including discrimination on the basis of race, color, religion, national origin, sex, sexual orientation, gender identity, gender expression, age, disability, genetic information, citizenship status, or veteran status. To learn more, please visit: https://jobs.utsouthwestern.edu/why-work-here/diversity-inclusion.
